Chromoanagenesis in Osteosarcoma

Chromoanagenesis in Osteosarcoma

Chromoanagenesis is a catastrophic genomic phenomenon involving sudden, extensive rearrangements within one or a few cell cycles. In osteosarcoma, the most prevalent malignant bone tumor in children and adolescents, these events dramatically alter the genomic landscape, frequently disrupting key tum...

Full description

Saved in:

Bibliographic Details
Main Authors:	Guozhuang Li, Nan Wu, Jen Ghabrial, Victoria Stinnett, Melanie Klausner, Laura Morsberger, Patty Long, Ezra Baraban, John M. Gross, Ying S. Zou
Format:	Article
Language:	English
Published:	MDPI AG 2025-06-01
Series:	Biomolecules
Subjects:	chromoanagenesis osteosarcoma structural variant chromothripsis chromoanasynthesis copy number variant
Online Access:	https://www.mdpi.com/2218-273X/15/6/833
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Participation of retroelements in chromoanagenesis in cancer development
by: R. N. Mustafin
Published: (2024-11-01)

Identification of Goat Supernumerary Teat Phenotype Using Wide-Genomic Copy Number Variants
by: Lu Xu, et al.
Published: (2024-11-01)

A specialized reference panel with structural variants integration for improving genotype imputation in Alzheimer disease and related dementias
by: Po-Liang Cheng, et al.
Published: (2025-10-01)

Copy Number Variants in Epileptic Encephalopathy
by: J Gordon Millichap
Published: (2012-02-01)

Exome sequencing of patients with syndromic tall stature reveals four novel candidate genes
by: Gabriela Jeesoo Kim, et al.
Published: (2025-07-01)

Expression of kinetochore component NDC80 promotes esophageal squamous cell carcinoma cells proliferation and migration
by: Youwu Shi, et al.
Published: (2025-06-01)

Diagnostic yield of expanded carrier screening of a multi-ethnic population in yunnan, China
by: Huizi Wang, et al.
Published: (2025-07-01)

KRAS amplification in colorectal cancer: correlations with clinicopathological features and prognosis in patients and prediction of response to targeted therapy
by: Xuanhua Yang, et al.
Published: (2025-07-01)

Optical Genome Mapping ( OGM) : Looking beyond karyotyping
by: Ruby Dhar, et al.
Published: (2025-01-01)

Impact of ASXL1 Gene Alterations on Myelodysplastic Syndrome With Isolated 20q Deletion
by: Yanan Chang, et al.
Published: (2025-03-01)

Patterns of Cytogenomic Findings from a Case Series of Recurrent Pregnancy Loss Provide Insight into the Extent of Genetic Defects Causing Miscarriages
by: Autumn DiAdamo, et al.
Published: (2024-01-01)

Copy Number Variants in Cardiac Channelopathies: Still a Missed Part in Routine Arrhythmic Diagnostics
by: Maria Gnazzo, et al.
Published: (2024-11-01)

Long read whole genome sequencing-based discovery of structural variants and their role in aetiology of non-syndromic autism spectrum disorder in India
by: Jhanvi Shah, et al.
Published: (2025-08-01)

Chromothripsis in Treatment Resistance in Multiple Myeloma
by: Kyoung Joo Lee, et al.
Published: (2017-09-01)

Prenatal diagnosis and genetic assessment of fetuses with single umbilical artery using chromosomal microarray analysis: a seven-year single-center retrospective study
by: Jianlong Zhuang, et al.
Published: (2025-07-01)

Long-Read Sequencing and Structural Variant Detection: Unlocking the Hidden Genome in Rare Genetic Disorders
by: Efthalia Moustakli, et al.
Published: (2025-07-01)

Prevalence and impact of molecular variation in the three-prime repair exonuclease 1 TREX1 and its implications for oncology
by: Marwa Shekfeh, et al.
Published: (2025-06-01)

Noninvasive Prenatal Testing Using Fetal Fraction Enrichment—A Pilot Study
by: Yun Chen, et al.
Published: (2024-05-01)

A cross-sectional study comparing machine learning and logistic regression techniques for predicting osteoporosis in a group at high risk of cardiovascular disease among old adults
by: Yuyi Peng, et al.
Published: (2025-03-01)

The hidden causes of pregnancy loss: a closer look
by: Panlai Shi, et al.
Published: (2025-06-01)

Genetics in prenatal diagnosis
by: Karen Mei Xian Lim, et al.
Published: (2023-01-01)

Effective detection of 148 cases chromosomal mosaicism by karyotyping, chromosomal microarray analysis and QF-PCR in 32,967 prenatal diagnoses
by: Yi Deng, et al.
Published: (2025-04-01)

Comparative study of tools for copy number variation detection using next-generation sequencing data
by: Ruchao Du, et al.
Published: (2025-07-01)

Application of copy number variation sequencing combined with whole exome sequencing in prenatal left–right asymmetry disorders
by: Yu Qin, et al.
Published: (2025-01-01)

Chromothripsis in Oncology: Literature Review and Case Report
by: NN Mamaev, et al.
Published: (2017-04-01)

Genomic landscape of childhood acute lymphoblastic leukemia in Malaysia: insights from array-CGH
by: Azli Ismail, et al.
Published: (2025-03-01)

Hearing problems in humans and mouse models with rare copy number variants associated with schizophrenia: a scoping review protocol [version 2; peer review: 2 approved, 1 approved with reservations]
by: Noushin Saadullah Khani, et al.
Published: (2024-12-01)

Gain of 20q11.21 in human pluripotent stem cells enhances differentiation to retinal pigment epithelium
by: Loriana Vitillo, et al.
Published: (2025-02-01)

Deep clinical and genetic analysis of 17p13.3 region: 38 pediatric patients diagnosed using next-generation sequencing and literature review
by: Xiaoshan Ji, et al.
Published: (2025-05-01)

Developmental milestones and cognitive trajectories in school-aged children with 16p11.2 deletion
by: Jente Verbesselt, et al.
Published: (2025-06-01)

Multidisciplinary approach to the accurate diagnosis of parosteal osteosarcoma
by: Miroslav Kilian, et al.
Published: (2025-07-01)

A Multi-Well Method for the CD138 and AML/MDS FISH Testing of Multiple Biomarkers on a Single Slide in Multiple Myeloma and AML/MDS Patients
by: Frank Tambini, et al.
Published: (2025-06-01)

Identification of Long Noncoding RNA Candidate Disease Genes Associated With Clinically Reported Copy Number Variants in Congenital Heart Disease
by: Jacqueline S. Penaloza, et al.
Published: (2025-03-01)

Clinical Characteristics and Outcomes of Hospitalized COVID-19 Patients with Different Variants of SARS-CoV-2 in a Tertiary Care Hospital, Thailand
by: Kitchawan Hengkrawit, et al.
Published: (2024-11-01)

A case of primary extraskeletal osteosarcoma of the breast
by: Kanako Kurata, et al.
Published: (2018-09-01)

Osteosarcoma of the larynx: rare clinical case
by: T. A. Aketova, et al.
Published: (2018-04-01)

Congenital heart disease presentations in the 15q11.2 microdeletion syndrome
by: Claudia-Ioana Fifirig, et al.
Published: (2025-03-01)

Brain Metastasis in Pediatric Patients with Osteosarcoma
by: Jacob Murphy, et al.
Published: (2024-11-01)

Metastatic Osteosarcoma of Lacrimal Gland
by: Smitha K Shambhu, et al.
Published: (2017-07-01)

Estudio contrastivo lingüístico y semántico de las construcciones verbales fijas diatópicas mexicanas/españolas
by: Pedro Mogorrón Huerta
Published: (2014-08-01)