ETV4/ALYREF-mediated glycolytic metabolism through PKM2 enhances resistance to ferroptosis and promotes the development of intrahepatic cholangiocarcinoma

ETV4/ALYREF-mediated glycolytic metabolism through PKM2 enhances resistance to ferroptosis and promotes the development of intrahepatic cholangiocarcinoma

Abstract Background Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatocellular cancer. This study investigated whether ETV4, ALYREF, and PKM2 affect glycolytic metabolism and ferroptosis, thereby potentially influencing ICC. Methods Bioinformatic analysis was used to expl...

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Bibliographic Details
Main Authors: Xiaohui Wang, Wenbin Duan, Zhongzhi Ma, Haoquan Wen, Xianhai Mao, Changjun Liu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cancer & Metabolism
Subjects:
ICC
PKM2
ETV4
ALYREF
Glycolytic metabolism
Ferroptosis
Online Access:https://doi.org/10.1186/s40170-025-00387-1
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