Knockout of cyclin-dependent kinases 8 and 19 leads to depletion of cyclin C and suppresses spermatogenesis and male fertility in mice

Knockout of cyclin-dependent kinases 8 and 19 leads to depletion of cyclin C and suppresses spermatogenesis and male fertility in mice

CDK8 and CDK19 paralogs are regulatory kinases associated with the transcriptional Mediator complex. We have generated mice with the systemic inducible Cdk8 knockout on the background of Cdk19 constitutive knockout. Cdk8/19 double knockout (iDKO) males, but not single Cdk8 or Cdk19 KO, had an atroph...

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Main Authors: Alexandra V Bruter, Ekaterina A Varlamova, Nina I Stavskaya, Zoia G Antysheva, Vasily N Manskikh, Anna V Tvorogova, Diana S Korshunova, Alvina I Khamidullina, Marina V Utkina, Viktor P Bogdanov, Iuliia P Baikova, Alyona I Nikiforova, Eugene A Albert, Denis O Maksimov, Jing Li, Mengqian Chen, Gary P Schools, Alexey V Feoktistov, Alexander A Shtil, Igor B Roninson, Vladislav A Mogila, Yulia Y Silaeva, Victor V Tatarskiy
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
CDK8
CDK19
Spermatogenesis
Online Access:https://elifesciences.org/articles/96465
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