The relationship of growth differentiation factor 15 with some biochemical parameters in cardiovascular disease patients in Babylon City
Abstract Background: Cardiovascular disease (CVD) is one of the reasons of mortality in the world. In the developing world, deaths from CVD have been increasing. Growth differentiation factor 15 (GDF15) is about cachexia, CVD, and a lot of inflammatory diseases. GDF15 is very low in most tissues, ex...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Medical Journal of Babylon |
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| Online Access: | https://doi.org/10.4103/MJBL.MJBL_371_23 |
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| author | Hiba Resheed Behayaa Zinah Abbass Ali Seenaa Badr Mohammed Suhayr A. Alqaysi |
| author_facet | Hiba Resheed Behayaa Zinah Abbass Ali Seenaa Badr Mohammed Suhayr A. Alqaysi |
| author_sort | Hiba Resheed Behayaa |
| collection | DOAJ |
| description | Abstract Background: Cardiovascular disease (CVD) is one of the reasons of mortality in the world. In the developing world, deaths from CVD have been increasing. Growth differentiation factor 15 (GDF15) is about cachexia, CVD, and a lot of inflammatory diseases. GDF15 is very low in most tissues, except the placenta (in healthy conditions), which expresses GDF15 in high levels. Though in cardiovascular damage, the level of GDF15 may rise, the natural effects of GDF15 may vary according to the stage of the disease. Objective: The objective of the study was the valuation of GDF15 level in the serum of patients with CVD in Babylon City and to check whether there was a link between age, body mass index, lipid profile, insulin resistance, adiponectin and C-reactive protein with GDF15. Materials and Methods: GDF15 was assessed in 80 Iraqi subjects; 40 were diagnosed with CVD and 40 subjects who appear healthy were considered for this study. The age ranged between 41 and 73 years for patients and control was considered for this study. Enzyme-linked immunosorbent assay technique was used for GDF15 estimation. Results: The results suggested that the serum levels of GDF15 and homeostatic model assessment for insulin resistance displayed a non-significant difference among studied groups (P > 0.05), whereas total cholesterol, high-density lipoprotein, triglyceride, adiponectin, and C-reactive protein appeared to have a significant difference among studied groups (P < 0.05). In contrast, the current study observed a non-significant (P > 0.05) association for GDF15 with all the clinical and biochemical parameters measured in this study. Conclusion: The study concluded that among the patients with CVD, the level of GDF15 revealed a non-significant relationship with the disease. |
| format | Article |
| id | doaj-art-9f57ca2282f94b16af21c85cd08cdfa7 |
| institution | Kabale University |
| issn | 1812-156X 2312-6760 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Babylon |
| spelling | doaj-art-9f57ca2282f94b16af21c85cd08cdfa72025-01-25T10:14:50ZengWolters Kluwer Medknow PublicationsMedical Journal of Babylon1812-156X2312-67602024-01-0121111211710.4103/MJBL.MJBL_371_23The relationship of growth differentiation factor 15 with some biochemical parameters in cardiovascular disease patients in Babylon CityHiba Resheed BehayaaZinah Abbass AliSeenaa Badr MohammedSuhayr A. AlqaysiAbstract Background: Cardiovascular disease (CVD) is one of the reasons of mortality in the world. In the developing world, deaths from CVD have been increasing. Growth differentiation factor 15 (GDF15) is about cachexia, CVD, and a lot of inflammatory diseases. GDF15 is very low in most tissues, except the placenta (in healthy conditions), which expresses GDF15 in high levels. Though in cardiovascular damage, the level of GDF15 may rise, the natural effects of GDF15 may vary according to the stage of the disease. Objective: The objective of the study was the valuation of GDF15 level in the serum of patients with CVD in Babylon City and to check whether there was a link between age, body mass index, lipid profile, insulin resistance, adiponectin and C-reactive protein with GDF15. Materials and Methods: GDF15 was assessed in 80 Iraqi subjects; 40 were diagnosed with CVD and 40 subjects who appear healthy were considered for this study. The age ranged between 41 and 73 years for patients and control was considered for this study. Enzyme-linked immunosorbent assay technique was used for GDF15 estimation. Results: The results suggested that the serum levels of GDF15 and homeostatic model assessment for insulin resistance displayed a non-significant difference among studied groups (P > 0.05), whereas total cholesterol, high-density lipoprotein, triglyceride, adiponectin, and C-reactive protein appeared to have a significant difference among studied groups (P < 0.05). In contrast, the current study observed a non-significant (P > 0.05) association for GDF15 with all the clinical and biochemical parameters measured in this study. Conclusion: The study concluded that among the patients with CVD, the level of GDF15 revealed a non-significant relationship with the disease.https://doi.org/10.4103/MJBL.MJBL_371_23adiponectincardiovascular diseasec-reactive proteingrowth differentiation factor 15 |
| spellingShingle | Hiba Resheed Behayaa Zinah Abbass Ali Seenaa Badr Mohammed Suhayr A. Alqaysi The relationship of growth differentiation factor 15 with some biochemical parameters in cardiovascular disease patients in Babylon City Medical Journal of Babylon adiponectin cardiovascular disease c-reactive protein growth differentiation factor 15 |
| title | The relationship of growth differentiation factor 15 with some biochemical parameters in cardiovascular disease patients in Babylon City |
| title_full | The relationship of growth differentiation factor 15 with some biochemical parameters in cardiovascular disease patients in Babylon City |
| title_fullStr | The relationship of growth differentiation factor 15 with some biochemical parameters in cardiovascular disease patients in Babylon City |
| title_full_unstemmed | The relationship of growth differentiation factor 15 with some biochemical parameters in cardiovascular disease patients in Babylon City |
| title_short | The relationship of growth differentiation factor 15 with some biochemical parameters in cardiovascular disease patients in Babylon City |
| title_sort | relationship of growth differentiation factor 15 with some biochemical parameters in cardiovascular disease patients in babylon city |
| topic | adiponectin cardiovascular disease c-reactive protein growth differentiation factor 15 |
| url | https://doi.org/10.4103/MJBL.MJBL_371_23 |
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