Minimizing DNA trapping while maintaining activity inhibition via selective PARP1 degrader

Minimizing DNA trapping while maintaining activity inhibition via selective PARP1 degrader

Abstract Poly (ADP-ribose) polymerase 1 (PARP1) catalyzes poly (ADP) ribosylation reaction, one of the essential post-translational modifications of proteins in eukaryotic cells. Given that PARP1 inhibition can lead to synthetic lethality in cells with compromised homologous recombination, this enzy...

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Bibliographic Details
Main Authors: Li Chen, Yahui Zou, Renhong Sun, Mei Huang, Xiaotong Zhu, Xiao Tang, Xiaobao Yang, Dake Li, Gaofeng Fan, Yu Wang
Format: Article
Language:English
Published: Nature Publishing Group 2024-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-07277-2
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