Synaptic disruption and CREB‐regulated transcription are restored by K+ channel blockers in ALS

Synaptic disruption and CREB‐regulated transcription are restored by K+ channel blockers in ALS

Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, which is still missing effective therapeutic strategies. Although manipulation of neuronal excitability has been tested in murine and human ALS models, it is still under debate whether neuronal activity might represen...

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Main Authors: Alberto Catanese, Sandeep Rajkumar, Daniel Sommer, Dennis Freisem, Alexander Wirth, Amr Aly, David Massa‐López, Andrea Olivieri, Federica Torelli, Valentin Ioannidis, Joanna Lipecka, Ida Chiara Guerrera, Daniel Zytnicki, Albert Ludolph, Edor Kabashi, Medhanie A Mulaw, Francesco Roselli, Tobias M Böckers
Format: Article
Language:English
Published: Springer Nature 2021-06-01
Series:EMBO Molecular Medicine
Subjects:
ALS
CREB
hiPSC
motoneuron
synapse
Online Access:https://doi.org/10.15252/emmm.202013131
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https://doi.org/10.15252/emmm.202013131

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