scExtract: leveraging large language models for fully automated single-cell RNA-seq data annotation and prior-informed multi-dataset integration

Abstract Single-cell RNA sequencing has revolutionized cellular heterogeneity research, but analyzing the abundance of unannotated public datasets remains challenging. We present scExtract, a framework leveraging large language models to automate scRNA-seq data analysis from preprocessing to annotat...

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Bibliographic Details
Main Authors: Yuxuan Wu, Fuchou Tang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Genome Biology
Subjects:
Online Access:https://doi.org/10.1186/s13059-025-03639-x
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