The role of cyclooxygenase-2 (COX-2) and inflammatory markers in the progress of Alport syndrome in Egyptian children
Abstract Background Chronic inflammation and its control are crucial to the responses of glomerular and renal tubular cells. This contributes to the pathogenic mechanisms and advancement of the disease in Alport syndrome. The study aimed to elucidate the role of cyclooxygenase-2, Interleukin 4, Plas...
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2025-01-01
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| Series: | BMC Pediatrics |
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| Online Access: | https://doi.org/10.1186/s12887-025-05412-2 |
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| author | Moushira Zaki Hisham A. Orban Mohamed A. Shahba Rehab S. I. Moustafa Ahmed Adel Fatina I. Fadel Abeer Selim Hala T. El-Bassyouni Eman R. Youness |
| author_facet | Moushira Zaki Hisham A. Orban Mohamed A. Shahba Rehab S. I. Moustafa Ahmed Adel Fatina I. Fadel Abeer Selim Hala T. El-Bassyouni Eman R. Youness |
| author_sort | Moushira Zaki |
| collection | DOAJ |
| description | Abstract Background Chronic inflammation and its control are crucial to the responses of glomerular and renal tubular cells. This contributes to the pathogenic mechanisms and advancement of the disease in Alport syndrome. The study aimed to elucidate the role of cyclooxygenase-2, Interleukin 4, Plasminogen activating inhibitor 1, and Prostaglandin E2 in the development and course of Alport syndrome. Methods In our study inflammatory markers were evaluated in 26 Alport syndrome patients, 15 males and 11 females and 24 controls. Results Their age ranged from 4 to 16 years (mean ± SD was 8.50 ± 2.877) and 24 were normal controls matching age and sex. The serum levels of cyclooxygenase-2, Prostaglandin E2, Interleukin 4, and Plasminogen activating inhibitor 1 were evaluated in all patients. The serum level of cyclooxygenase-2, Prostaglandin E2, Interleukin 4, and Plasminogen activating inhibitor 1 were all increased significantly in the Alport syndrome patients compared to control (588.68 ± 73.08, 42.57 ± 4.18, 42.32 ± 3.49, and 846.47 ± 45.433, respectively versus controls (369.12 ± 50.28, 25.52 ± 4.98, 28.89 ± 3.19, and 312.79 ± 40.53 respectively). Conclusion The role of inflammatory markers cyclooxygenase-2, Prostaglandin E2, Interleukin 4, and Plasminogen activating inhibitor 1 in Alport syndrome that are causally connected and have a role in the development and course of Alport disease was delineated. This may highlight and speculate an innovative strategy for targeting the creation of safe and efficient anti-inflammatory treatments to inhibit disease progression in Alport syndrome. |
| format | Article |
| id | doaj-art-9f3164af0dcb4dc8b8ff70c526ba8ae2 |
| institution | Kabale University |
| issn | 1471-2431 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj-art-9f3164af0dcb4dc8b8ff70c526ba8ae22025-01-26T12:52:53ZengBMCBMC Pediatrics1471-24312025-01-012511510.1186/s12887-025-05412-2The role of cyclooxygenase-2 (COX-2) and inflammatory markers in the progress of Alport syndrome in Egyptian childrenMoushira Zaki0Hisham A. Orban1Mohamed A. Shahba2Rehab S. I. Moustafa3Ahmed Adel4Fatina I. Fadel5Abeer Selim6Hala T. El-Bassyouni7Eman R. Youness8Biological Anthropology Department, Medical Research and Clinical Studies Institute, National Research CentreMedical Biochemistry Department, Medical Research and Clinical Studies Institute, National Research CentreMedical Biochemistry Department, Medical Research and Clinical Studies Institute, National Research CentreChild Health Department, Medical Research and Clinical Studies Institute, National Research CentreChild Health Department, Medical Research and Clinical Studies Institute, National Research CentreDepartment of Pediatrics, Pediatric Nephrology Unit. Kasr Al-Ainy Faculty of Medicine, Cairo UniversityDepartment of Pediatrics, Medical Research and Clinical Studies Institute, National Research CentreClinical Genetics Department, Human Genetics and Genome Research Institute, National Research CentreMedical Biochemistry Department, Medical Research and Clinical Studies Institute, National Research CentreAbstract Background Chronic inflammation and its control are crucial to the responses of glomerular and renal tubular cells. This contributes to the pathogenic mechanisms and advancement of the disease in Alport syndrome. The study aimed to elucidate the role of cyclooxygenase-2, Interleukin 4, Plasminogen activating inhibitor 1, and Prostaglandin E2 in the development and course of Alport syndrome. Methods In our study inflammatory markers were evaluated in 26 Alport syndrome patients, 15 males and 11 females and 24 controls. Results Their age ranged from 4 to 16 years (mean ± SD was 8.50 ± 2.877) and 24 were normal controls matching age and sex. The serum levels of cyclooxygenase-2, Prostaglandin E2, Interleukin 4, and Plasminogen activating inhibitor 1 were evaluated in all patients. The serum level of cyclooxygenase-2, Prostaglandin E2, Interleukin 4, and Plasminogen activating inhibitor 1 were all increased significantly in the Alport syndrome patients compared to control (588.68 ± 73.08, 42.57 ± 4.18, 42.32 ± 3.49, and 846.47 ± 45.433, respectively versus controls (369.12 ± 50.28, 25.52 ± 4.98, 28.89 ± 3.19, and 312.79 ± 40.53 respectively). Conclusion The role of inflammatory markers cyclooxygenase-2, Prostaglandin E2, Interleukin 4, and Plasminogen activating inhibitor 1 in Alport syndrome that are causally connected and have a role in the development and course of Alport disease was delineated. This may highlight and speculate an innovative strategy for targeting the creation of safe and efficient anti-inflammatory treatments to inhibit disease progression in Alport syndrome.https://doi.org/10.1186/s12887-025-05412-2Alport syndromeCyclooxygenase-2Interleukin 4Plasminogen activating inhibitor 1Prostaglandin E2 |
| spellingShingle | Moushira Zaki Hisham A. Orban Mohamed A. Shahba Rehab S. I. Moustafa Ahmed Adel Fatina I. Fadel Abeer Selim Hala T. El-Bassyouni Eman R. Youness The role of cyclooxygenase-2 (COX-2) and inflammatory markers in the progress of Alport syndrome in Egyptian children BMC Pediatrics Alport syndrome Cyclooxygenase-2 Interleukin 4 Plasminogen activating inhibitor 1 Prostaglandin E2 |
| title | The role of cyclooxygenase-2 (COX-2) and inflammatory markers in the progress of Alport syndrome in Egyptian children |
| title_full | The role of cyclooxygenase-2 (COX-2) and inflammatory markers in the progress of Alport syndrome in Egyptian children |
| title_fullStr | The role of cyclooxygenase-2 (COX-2) and inflammatory markers in the progress of Alport syndrome in Egyptian children |
| title_full_unstemmed | The role of cyclooxygenase-2 (COX-2) and inflammatory markers in the progress of Alport syndrome in Egyptian children |
| title_short | The role of cyclooxygenase-2 (COX-2) and inflammatory markers in the progress of Alport syndrome in Egyptian children |
| title_sort | role of cyclooxygenase 2 cox 2 and inflammatory markers in the progress of alport syndrome in egyptian children |
| topic | Alport syndrome Cyclooxygenase-2 Interleukin 4 Plasminogen activating inhibitor 1 Prostaglandin E2 |
| url | https://doi.org/10.1186/s12887-025-05412-2 |
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