White matter hyperintensities and their impact in brain structure and function in alzheimer’s disease and behavioral variant frontotemporal dementia across Latin America and the United States: a cross-sectional study

White matter hyperintensities and their impact in brain structure and function in alzheimer’s disease and behavioral variant frontotemporal dementia across Latin America and the United States: a cross-sectional study

Abstract Background White matter hyperintensities (WMHs) are a core manifestation of normal and pathological aging and are potentially linked to geographical differences in social and physical exposomes. Previous studies have not examined the impact of WMHs burden on neurodegeneration and cognition...

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Main Authors: Florencia Altschuler, Verónica Canziani, Matías Fraile-Vázquez, Raul Gonzalez-Gomez, Hernán Hernández, Sandra Baez, Joaquín Migeot, Sol Fittipaldi, Marcelo Adrian Maito, Agustina Legaz, Maria Eugenia Godoy, Sebastián Moguilner, Josephine Cruzat, Carlos Coronel-Oliveros, Enzo Tagliazucchi, Hernando Santamaria Garcia, Pablo Reyes, Diana L. Matallana, José Alberto Avila-Funes, Andrea Slachevsky, María I. Behrens, Nilton Custodio, Juan Felipe Cardona, Luis Ignacio Brusco, Martin A. Bruno, Ana L. Sosa Ortiz, Stefanie D. Pina-Escudero, Leonel T. Takada, Elisa de Paula Franca Resende, Katherine L. Possin, Maira Okada de Oliveira, Kun Hu, Brian Lawlor, Jennifer S. Yokoyama, Bruce Miller, Francisco Lopera, Adolfo Martin Garcia, Vicente Medel, Agustin Ibañez, Cecilia Gonzalez Campo
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Alzheimer’s Research & Therapy
Subjects:
MRI
Frontotemporal dementia
Alzheimer’s disease
White Matter Hyperintensities
Latin America
Online Access:https://doi.org/10.1186/s13195-025-01832-5
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https://doi.org/10.1186/s13195-025-01832-5

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