Gentamicin Induced Nephrotoxicity: The Role of Sex Hormones in Gonadectomized Male and Female Rats
Background. Gentamicin (GM) induced nephrotoxicity may be sex hormones related. The effects of sex hormones on GM induced nephrotoxicity in gonadectomized rats were investigated. Methods. Ovariectomized rats received 0.25, 0.5, or 1 mg/kg/week of estradiol (ES) alone or accompanied with 10 mg/kg/wee...
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Wiley
2016-01-01
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| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2016/5025097 |
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| author | Fatemeh Eshraghi-Jazi Ardeshir Talebi Fatemeh Sadat Mirsaeedi Sarina Ahmadian Fatemeh Moslemi Mehdi Nematbakhsh |
| author_facet | Fatemeh Eshraghi-Jazi Ardeshir Talebi Fatemeh Sadat Mirsaeedi Sarina Ahmadian Fatemeh Moslemi Mehdi Nematbakhsh |
| author_sort | Fatemeh Eshraghi-Jazi |
| collection | DOAJ |
| description | Background. Gentamicin (GM) induced nephrotoxicity may be sex hormones related. The effects of sex hormones on GM induced nephrotoxicity in gonadectomized rats were investigated. Methods. Ovariectomized rats received 0.25, 0.5, or 1 mg/kg/week of estradiol (ES) alone or accompanied with 10 mg/kg/week of progesterone (Pro) for two weeks followed by GM (100 mg/kg/day) for 9 days. Castrated rats were also treated with 10, 50, or 100 mg/kg/week of testosterone (TS) for two weeks and then received GM. In addition, a single castrated group received 0.25 mg/kg/week of ES plus GM. Results. GM increased the serum levels of blood urea nitrogen (BUN) and creatinine (Cr) and kidney tissue damage score (KTDS) (P<0.05). TS had no effect on the serum levels of BUN and Cr and KTDS, while low dose of ES intensified these parameters in male (P<0.05). ES (0.5 mg/kg) without Pro ameliorated KTDS in female (P<0.05) while ES (1 mg/kg) with or without Pro exacerbated the BUN values and Cr values, KTDS, and body weight loss (P<0.05). Conclusion. ES (0.5 mg/kg) without Pro ameliorated kidney damage induced by GM in female while neither TS nor ES had beneficial effect on nephrotoxicity induced by GM in male, although ES aggravated it. |
| format | Article |
| id | doaj-art-9ec24d661ca4403bbcb5dc8de0c652f4 |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-9ec24d661ca4403bbcb5dc8de0c652f42025-02-03T06:44:18ZengWileyScientifica2090-908X2016-01-01201610.1155/2016/50250975025097Gentamicin Induced Nephrotoxicity: The Role of Sex Hormones in Gonadectomized Male and Female RatsFatemeh Eshraghi-Jazi0Ardeshir Talebi1Fatemeh Sadat Mirsaeedi2Sarina Ahmadian3Fatemeh Moslemi4Mehdi Nematbakhsh5Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, IranWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, IranWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, IranWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, IranWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, IranWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, IranBackground. Gentamicin (GM) induced nephrotoxicity may be sex hormones related. The effects of sex hormones on GM induced nephrotoxicity in gonadectomized rats were investigated. Methods. Ovariectomized rats received 0.25, 0.5, or 1 mg/kg/week of estradiol (ES) alone or accompanied with 10 mg/kg/week of progesterone (Pro) for two weeks followed by GM (100 mg/kg/day) for 9 days. Castrated rats were also treated with 10, 50, or 100 mg/kg/week of testosterone (TS) for two weeks and then received GM. In addition, a single castrated group received 0.25 mg/kg/week of ES plus GM. Results. GM increased the serum levels of blood urea nitrogen (BUN) and creatinine (Cr) and kidney tissue damage score (KTDS) (P<0.05). TS had no effect on the serum levels of BUN and Cr and KTDS, while low dose of ES intensified these parameters in male (P<0.05). ES (0.5 mg/kg) without Pro ameliorated KTDS in female (P<0.05) while ES (1 mg/kg) with or without Pro exacerbated the BUN values and Cr values, KTDS, and body weight loss (P<0.05). Conclusion. ES (0.5 mg/kg) without Pro ameliorated kidney damage induced by GM in female while neither TS nor ES had beneficial effect on nephrotoxicity induced by GM in male, although ES aggravated it.http://dx.doi.org/10.1155/2016/5025097 |
| spellingShingle | Fatemeh Eshraghi-Jazi Ardeshir Talebi Fatemeh Sadat Mirsaeedi Sarina Ahmadian Fatemeh Moslemi Mehdi Nematbakhsh Gentamicin Induced Nephrotoxicity: The Role of Sex Hormones in Gonadectomized Male and Female Rats Scientifica |
| title | Gentamicin Induced Nephrotoxicity: The Role of Sex Hormones in Gonadectomized Male and Female Rats |
| title_full | Gentamicin Induced Nephrotoxicity: The Role of Sex Hormones in Gonadectomized Male and Female Rats |
| title_fullStr | Gentamicin Induced Nephrotoxicity: The Role of Sex Hormones in Gonadectomized Male and Female Rats |
| title_full_unstemmed | Gentamicin Induced Nephrotoxicity: The Role of Sex Hormones in Gonadectomized Male and Female Rats |
| title_short | Gentamicin Induced Nephrotoxicity: The Role of Sex Hormones in Gonadectomized Male and Female Rats |
| title_sort | gentamicin induced nephrotoxicity the role of sex hormones in gonadectomized male and female rats |
| url | http://dx.doi.org/10.1155/2016/5025097 |
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