Lysyl oxidase promotes seminal vesicle atrophy and fibrosis in type-2 diabetes mellitus through TGF-β1 signaling

Lysyl oxidase promotes seminal vesicle atrophy and fibrosis in type-2 diabetes mellitus through TGF-β1 signaling

Abstract Type-2 diabetes mellitus (T2DM) is a complex metabolic disorder that adversely affects various physiological systems, particularly male reproductive health. Research indicates that T2DM increases the risk of retrograde ejaculation, impairing sexual function and fertility. Dysregulation of l...

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Main Authors: Yi Yu, Peng-Fei Liu, Ming-Wei Zhan, Yao-Qi Chen, Yu-Qi Lai, Lei Wang, Jun-Jie Wu, Fan Yao, Xue-Qin Chen, Xue-Jun Shang, Ke-Rong Wu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Lysyl oxidase
Type-2 diabetes mellitus
TGF-β1
Seminal vesicle
Fibrosis
Apoptosis
Online Access:https://doi.org/10.1186/s12967-025-06590-4
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https://doi.org/10.1186/s12967-025-06590-4

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