Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive Immunity
Dendritic cells (DCs) are considered as one of the main regulators of immune responses. They collect antigens, process them, and present typical antigenic structures to lymphocytes, thereby inducing an adaptive immune response. All these processes take place under conditions of oxygen shortage (hypo...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/5134329 |
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| _version_ | 1832564556135661568 |
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| author | Sandra Winning Joachim Fandrey |
| author_facet | Sandra Winning Joachim Fandrey |
| author_sort | Sandra Winning |
| collection | DOAJ |
| description | Dendritic cells (DCs) are considered as one of the main regulators of immune responses. They collect antigens, process them, and present typical antigenic structures to lymphocytes, thereby inducing an adaptive immune response. All these processes take place under conditions of oxygen shortage (hypoxia) which is often not considered in experimental settings. This review highlights how deeply hypoxia modulates human as well as mouse immature and mature dendritic cell functions. It tries to link in vitro results to actual in vivo studies and outlines how hypoxia-mediated shaping of dendritic cells affects the activation of (innate) immunity. |
| format | Article |
| id | doaj-art-9e938c5101574fa18ff96b1ac8c79fe4 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
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| series | Journal of Immunology Research |
| spelling | doaj-art-9e938c5101574fa18ff96b1ac8c79fe42025-02-03T01:10:47ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/51343295134329Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive ImmunitySandra Winning0Joachim Fandrey1Institut für Physiologie, Universität Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, GermanyInstitut für Physiologie, Universität Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, GermanyDendritic cells (DCs) are considered as one of the main regulators of immune responses. They collect antigens, process them, and present typical antigenic structures to lymphocytes, thereby inducing an adaptive immune response. All these processes take place under conditions of oxygen shortage (hypoxia) which is often not considered in experimental settings. This review highlights how deeply hypoxia modulates human as well as mouse immature and mature dendritic cell functions. It tries to link in vitro results to actual in vivo studies and outlines how hypoxia-mediated shaping of dendritic cells affects the activation of (innate) immunity.http://dx.doi.org/10.1155/2016/5134329 |
| spellingShingle | Sandra Winning Joachim Fandrey Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive Immunity Journal of Immunology Research |
| title | Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive Immunity |
| title_full | Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive Immunity |
| title_fullStr | Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive Immunity |
| title_full_unstemmed | Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive Immunity |
| title_short | Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive Immunity |
| title_sort | dendritic cells under hypoxia how oxygen shortage affects the linkage between innate and adaptive immunity |
| url | http://dx.doi.org/10.1155/2016/5134329 |
| work_keys_str_mv | AT sandrawinning dendriticcellsunderhypoxiahowoxygenshortageaffectsthelinkagebetweeninnateandadaptiveimmunity AT joachimfandrey dendriticcellsunderhypoxiahowoxygenshortageaffectsthelinkagebetweeninnateandadaptiveimmunity |