Derivation of resident macrophages and construction of tumor microenvironment in Flk-1-knockout chimeric mice produced via blastocyst complementation

Derivation of resident macrophages and construction of tumor microenvironment in Flk-1-knockout chimeric mice produced via blastocyst complementation

Abstract The tumor microenvironment (TME) is deeply involved in cancer progression and treatment resistance. Although humanized mouse models have been developed by transplanting human cells into immunodeficient mice, they fail to fully reconstitute the TME. Blastocyst complementation using Flk-1 (Ve...

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Main Authors: Satoko Ishii, Kazuto Yamazaki, Peng Li, Kenji Kubara, Yuta Ishizuka, Yukina Izumi, Tsutomu Kamisako, Hiroyoshi Ishizaki, Yuichi Ono, Naoaki Mizuno, Hideyuki Sato, Hideki Masaki, Motoo Watanabe, Masashi Ito, Hiromitsu Nakauchi
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Blastocyst complementation
Tumor microenvironment
Tumor model
Resident macrophages
Online Access:https://doi.org/10.1038/s41598-025-12571-w
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https://doi.org/10.1038/s41598-025-12571-w

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