Pan-cancer analysis of homologous recombination deficiency and homologous recombination repair–associated gene alterations in solid tumors from a large Asian cohort

Pan-cancer analysis of homologous recombination deficiency and homologous recombination repair–associated gene alterations in solid tumors from a large Asian cohort

Abstract Background Homologous recombination deficiency (HRD) is associated with sensitivity to platinum-based chemotherapy and PARP inhibitors in BRCA-associated cancers, including ovarian, breast, prostate, and pancreatic cancers. This study explores HRD and homologous recombination repair (HRR) g...

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Bibliographic Details
Main Authors: Lili Ren, Runsi Yao, Ting Hou, Chenglin Liu, Fei Zhao, Xiaojun Chen, Zhou Zhang, Yan Huang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Cancer
Subjects:
Biallelic alterations
Genomic instability
Homologous recombination deficiency
Homologous recombination repair
TP53
Online Access:https://doi.org/10.1186/s12885-025-14267-w
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https://doi.org/10.1186/s12885-025-14267-w

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