Stem Cell-Derived Exosomes: A Potential Alternative Therapeutic Agent in Orthopaedics
Within the field of regenerative medicine, many have sought to use stem cells as a promising way to heal human tissue; however, in the past few years, exosomes (packaged vesicles released from cells) have shown more exciting promise. Specifically, stem cell-derived exosomes have demonstrated great a...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/5802529 |
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| _version_ | 1832565114772914176 |
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| author | John Burke Ravindra Kolhe Monte Hunter Carlos Isales Mark Hamrick Sadanand Fulzele |
| author_facet | John Burke Ravindra Kolhe Monte Hunter Carlos Isales Mark Hamrick Sadanand Fulzele |
| author_sort | John Burke |
| collection | DOAJ |
| description | Within the field of regenerative medicine, many have sought to use stem cells as a promising way to heal human tissue; however, in the past few years, exosomes (packaged vesicles released from cells) have shown more exciting promise. Specifically, stem cell-derived exosomes have demonstrated great ability to provide therapeutical benefits. Exosomal products can include miRNA, other genetic products, proteins, and various factors. They are released from cells in a paracrine fashion in order to combat local cellular stress. Because of this, there are vast benefits that medicine can obtain from stem cell-derived exosomes. If exosomes could be extracted from stem cells in an efficient manner and packaged with particular regenerative products, then diseases such as rheumatoid arthritis, osteoarthritis, bone fractures, and other maladies could be treated with cell-free regenerative medicine via exosomes. Many advances must be made to get to this point, and the following review highlights the current advances of stem cell-derived exosomes with particular attention to regenerative medicine in orthopaedics. |
| format | Article |
| id | doaj-art-9e8385b9ad6a453b9cf1ca16f652e178 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-9e8385b9ad6a453b9cf1ca16f652e1782025-02-03T01:09:22ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/58025295802529Stem Cell-Derived Exosomes: A Potential Alternative Therapeutic Agent in OrthopaedicsJohn Burke0Ravindra Kolhe1Monte Hunter2Carlos Isales3Mark Hamrick4Sadanand Fulzele5Department of Orthopedics, Georgia Regents University, Augusta, GA 30912, USADepartment of Pathology, Georgia Regents University, Augusta, GA 30912, USADepartment of Orthopedics, Georgia Regents University, Augusta, GA 30912, USADepartment of Orthopedics, Georgia Regents University, Augusta, GA 30912, USAInstitute of Regenerative and Reparative Medicine, Georgia Regents University, Augusta, GA 30912, USADepartment of Orthopedics, Georgia Regents University, Augusta, GA 30912, USAWithin the field of regenerative medicine, many have sought to use stem cells as a promising way to heal human tissue; however, in the past few years, exosomes (packaged vesicles released from cells) have shown more exciting promise. Specifically, stem cell-derived exosomes have demonstrated great ability to provide therapeutical benefits. Exosomal products can include miRNA, other genetic products, proteins, and various factors. They are released from cells in a paracrine fashion in order to combat local cellular stress. Because of this, there are vast benefits that medicine can obtain from stem cell-derived exosomes. If exosomes could be extracted from stem cells in an efficient manner and packaged with particular regenerative products, then diseases such as rheumatoid arthritis, osteoarthritis, bone fractures, and other maladies could be treated with cell-free regenerative medicine via exosomes. Many advances must be made to get to this point, and the following review highlights the current advances of stem cell-derived exosomes with particular attention to regenerative medicine in orthopaedics.http://dx.doi.org/10.1155/2016/5802529 |
| spellingShingle | John Burke Ravindra Kolhe Monte Hunter Carlos Isales Mark Hamrick Sadanand Fulzele Stem Cell-Derived Exosomes: A Potential Alternative Therapeutic Agent in Orthopaedics Stem Cells International |
| title | Stem Cell-Derived Exosomes: A Potential Alternative Therapeutic Agent in Orthopaedics |
| title_full | Stem Cell-Derived Exosomes: A Potential Alternative Therapeutic Agent in Orthopaedics |
| title_fullStr | Stem Cell-Derived Exosomes: A Potential Alternative Therapeutic Agent in Orthopaedics |
| title_full_unstemmed | Stem Cell-Derived Exosomes: A Potential Alternative Therapeutic Agent in Orthopaedics |
| title_short | Stem Cell-Derived Exosomes: A Potential Alternative Therapeutic Agent in Orthopaedics |
| title_sort | stem cell derived exosomes a potential alternative therapeutic agent in orthopaedics |
| url | http://dx.doi.org/10.1155/2016/5802529 |
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