A Nanostructured Cu(II) Coordination Polymer Based on Alanine as a Trifunctional Mimic Enzyme and Efficient Composite in the Detection of Sphingobacteria
This research raises the potential use of coordination polymers as new useful materials in two essential research fields, allowing the obtaining of a new multiartificial enzyme with the capacity to inhibit the growth of bacteria resistance. The fine selection of the ligands allows the design of a ne...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2022/8788221 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558403217522688 |
|---|---|
| author | Noelia Maldonado Ana Latorre Félix Zamora Álvaro Somoza Carlos J. Gómez-García Agatha Bastida Pilar Amo-Ochoa |
| author_facet | Noelia Maldonado Ana Latorre Félix Zamora Álvaro Somoza Carlos J. Gómez-García Agatha Bastida Pilar Amo-Ochoa |
| author_sort | Noelia Maldonado |
| collection | DOAJ |
| description | This research raises the potential use of coordination polymers as new useful materials in two essential research fields, allowing the obtaining of a new multiartificial enzyme with the capacity to inhibit the growth of bacteria resistance. The fine selection of the ligands allows the design of a new 2D coordination polymer (CP), with the formula [Cu2(IBA)2(OH2)4]n·6nH2O, by the combination of Cu (II) as the metal center with a pseudoamino acid (H2IBA = isophthaloyl bis β-alanine). Quantitative total X-ray fluorescence (TXRF) analyses show that the obtained CP can gradually release Cu (II) ions. Additionally, this CP can be nanoprocessed and transformed into a metal-organic gel (MOG) by using different Cu (II) salt concentrations and the application of ultrasounds. Considering its nanometric dimensions, the slow Cu (II) release and its simple processability, its performance as an artificial enzyme, and its antibacterial ability were explored. The results obtained show the first nanocoordination polymer acting as an artificial multienzyme (peroxidase, catalase, and superoxodismutase) exhibiting antibacterial activity in the presence of hydrogen peroxide, with selective behavior for three bacterium strains (S. spiritovirum, A. faecales, and B. cereus). Indeed, this CP shows a more robust inhibition capacity for Sphingobacterium. Going beyond that, as there are no comfortable and practically clinical tests capable of detecting the presence of Sphingobacteria, the compound can be easily embedded to form moldable gelatin that will facilitate the handling and low-cost commercial kits. |
| format | Article |
| id | doaj-art-9e831e8615b14336bb7d732e48673ccb |
| institution | Kabale University |
| issn | 1687-479X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-9e831e8615b14336bb7d732e48673ccb2025-02-03T01:32:33ZengWileyBioinorganic Chemistry and Applications1687-479X2022-01-01202210.1155/2022/8788221A Nanostructured Cu(II) Coordination Polymer Based on Alanine as a Trifunctional Mimic Enzyme and Efficient Composite in the Detection of SphingobacteriaNoelia Maldonado0Ana Latorre1Félix Zamora2Álvaro Somoza3Carlos J. Gómez-García4Agatha Bastida5Pilar Amo-Ochoa6Departamento de Química InorgánicaInstituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA Nanociencia)Departamento de Química InorgánicaInstituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA Nanociencia)Departamento de Química InorgánicaDepartamento de Química Bio-OrgánicaDepartamento de Química InorgánicaThis research raises the potential use of coordination polymers as new useful materials in two essential research fields, allowing the obtaining of a new multiartificial enzyme with the capacity to inhibit the growth of bacteria resistance. The fine selection of the ligands allows the design of a new 2D coordination polymer (CP), with the formula [Cu2(IBA)2(OH2)4]n·6nH2O, by the combination of Cu (II) as the metal center with a pseudoamino acid (H2IBA = isophthaloyl bis β-alanine). Quantitative total X-ray fluorescence (TXRF) analyses show that the obtained CP can gradually release Cu (II) ions. Additionally, this CP can be nanoprocessed and transformed into a metal-organic gel (MOG) by using different Cu (II) salt concentrations and the application of ultrasounds. Considering its nanometric dimensions, the slow Cu (II) release and its simple processability, its performance as an artificial enzyme, and its antibacterial ability were explored. The results obtained show the first nanocoordination polymer acting as an artificial multienzyme (peroxidase, catalase, and superoxodismutase) exhibiting antibacterial activity in the presence of hydrogen peroxide, with selective behavior for three bacterium strains (S. spiritovirum, A. faecales, and B. cereus). Indeed, this CP shows a more robust inhibition capacity for Sphingobacterium. Going beyond that, as there are no comfortable and practically clinical tests capable of detecting the presence of Sphingobacteria, the compound can be easily embedded to form moldable gelatin that will facilitate the handling and low-cost commercial kits.http://dx.doi.org/10.1155/2022/8788221 |
| spellingShingle | Noelia Maldonado Ana Latorre Félix Zamora Álvaro Somoza Carlos J. Gómez-García Agatha Bastida Pilar Amo-Ochoa A Nanostructured Cu(II) Coordination Polymer Based on Alanine as a Trifunctional Mimic Enzyme and Efficient Composite in the Detection of Sphingobacteria Bioinorganic Chemistry and Applications |
| title | A Nanostructured Cu(II) Coordination Polymer Based on Alanine as a Trifunctional Mimic Enzyme and Efficient Composite in the Detection of Sphingobacteria |
| title_full | A Nanostructured Cu(II) Coordination Polymer Based on Alanine as a Trifunctional Mimic Enzyme and Efficient Composite in the Detection of Sphingobacteria |
| title_fullStr | A Nanostructured Cu(II) Coordination Polymer Based on Alanine as a Trifunctional Mimic Enzyme and Efficient Composite in the Detection of Sphingobacteria |
| title_full_unstemmed | A Nanostructured Cu(II) Coordination Polymer Based on Alanine as a Trifunctional Mimic Enzyme and Efficient Composite in the Detection of Sphingobacteria |
| title_short | A Nanostructured Cu(II) Coordination Polymer Based on Alanine as a Trifunctional Mimic Enzyme and Efficient Composite in the Detection of Sphingobacteria |
| title_sort | nanostructured cu ii coordination polymer based on alanine as a trifunctional mimic enzyme and efficient composite in the detection of sphingobacteria |
| url | http://dx.doi.org/10.1155/2022/8788221 |
| work_keys_str_mv | AT noeliamaldonado ananostructuredcuiicoordinationpolymerbasedonalanineasatrifunctionalmimicenzymeandefficientcompositeinthedetectionofsphingobacteria AT analatorre ananostructuredcuiicoordinationpolymerbasedonalanineasatrifunctionalmimicenzymeandefficientcompositeinthedetectionofsphingobacteria AT felixzamora ananostructuredcuiicoordinationpolymerbasedonalanineasatrifunctionalmimicenzymeandefficientcompositeinthedetectionofsphingobacteria AT alvarosomoza ananostructuredcuiicoordinationpolymerbasedonalanineasatrifunctionalmimicenzymeandefficientcompositeinthedetectionofsphingobacteria AT carlosjgomezgarcia ananostructuredcuiicoordinationpolymerbasedonalanineasatrifunctionalmimicenzymeandefficientcompositeinthedetectionofsphingobacteria AT agathabastida ananostructuredcuiicoordinationpolymerbasedonalanineasatrifunctionalmimicenzymeandefficientcompositeinthedetectionofsphingobacteria AT pilaramoochoa ananostructuredcuiicoordinationpolymerbasedonalanineasatrifunctionalmimicenzymeandefficientcompositeinthedetectionofsphingobacteria AT noeliamaldonado nanostructuredcuiicoordinationpolymerbasedonalanineasatrifunctionalmimicenzymeandefficientcompositeinthedetectionofsphingobacteria AT analatorre nanostructuredcuiicoordinationpolymerbasedonalanineasatrifunctionalmimicenzymeandefficientcompositeinthedetectionofsphingobacteria AT felixzamora nanostructuredcuiicoordinationpolymerbasedonalanineasatrifunctionalmimicenzymeandefficientcompositeinthedetectionofsphingobacteria AT alvarosomoza nanostructuredcuiicoordinationpolymerbasedonalanineasatrifunctionalmimicenzymeandefficientcompositeinthedetectionofsphingobacteria AT carlosjgomezgarcia nanostructuredcuiicoordinationpolymerbasedonalanineasatrifunctionalmimicenzymeandefficientcompositeinthedetectionofsphingobacteria AT agathabastida nanostructuredcuiicoordinationpolymerbasedonalanineasatrifunctionalmimicenzymeandefficientcompositeinthedetectionofsphingobacteria AT pilaramoochoa nanostructuredcuiicoordinationpolymerbasedonalanineasatrifunctionalmimicenzymeandefficientcompositeinthedetectionofsphingobacteria |