Relationship of Asymmetrical Dimethylarginine, Nitric Oxide, and Sustained Attention during Attack in Patients with Major Depressive Disorder
We investigated the relationship of serum nitric oxide (NO) and asymmetrical dimethylarginine (ADMA) levels with cognitive functioning in patients with major depressive disorder (MDD). 41 MDD patients (Beck depression scale scores >16) and 44 controls were included in the study. Rey verbal learni...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/624395 |
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| author | Serpil Canpolat İsmet Kırpınar Erdem Deveci Hülya Aksoy Zafer Bayraktutan İbrahim Eren Recep Demir Salih Selek Nazan Aydın |
| author_facet | Serpil Canpolat İsmet Kırpınar Erdem Deveci Hülya Aksoy Zafer Bayraktutan İbrahim Eren Recep Demir Salih Selek Nazan Aydın |
| author_sort | Serpil Canpolat |
| collection | DOAJ |
| description | We investigated the relationship of serum nitric oxide (NO) and asymmetrical dimethylarginine (ADMA) levels with cognitive functioning in patients with major depressive disorder (MDD). 41 MDD patients (Beck depression scale scores >16) and 44 controls were included in the study. Rey verbal learning and memory test, auditory consonant trigram test, digit span test, Wisconsin card sorting test, continuous performance task (TOVA), and Stroop test scores were found to be impaired in patients with major depressive disorder when compared to healthy controls. There was no significant difference between patient and control groups in terms of serum NO and ADMA. Serum NO levels were correlated with TOVA test error scores and Stroop test time scores, whereas serum ADMA levels were negatively correlated with TOVA test error scores. Metabolic detriments especially in relation to NO metabolism in frontal cortex and hypothalamus, psychomotor retardation, or loss of motivation may explain these deficits. |
| format | Article |
| id | doaj-art-9e70f7b25bb0409a9688f54141b2216e |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-9e70f7b25bb0409a9688f54141b2216e2025-02-03T05:43:36ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/624395624395Relationship of Asymmetrical Dimethylarginine, Nitric Oxide, and Sustained Attention during Attack in Patients with Major Depressive DisorderSerpil Canpolat0İsmet Kırpınar1Erdem Deveci2Hülya Aksoy3Zafer Bayraktutan4İbrahim Eren5Recep Demir6Salih Selek7Nazan Aydın8Department of Psychiatry, Çumra State Hospital, 42500 Konya, TurkeyDepartment of Psychiatry, School of Medicine, Bezmialem Vakif University, 34093 Istanbul, TurkeyDepartment of Psychiatry, School of Medicine, Bezmialem Vakif University, 34093 Istanbul, TurkeyDepartment of Biochemistry, School of Medicine, Atatürk University, 25240 Erzurum, TurkeyDepartment of Biochemistry, School of Medicine, Atatürk University, 25240 Erzurum, TurkeyDepartment of Psychiatry, Konya Training and Research Hospital, 42090 Konya, TurkeyDepartment of Neurology, School of Medicine, Atatürk University, 25240 Erzurum, TurkeyDepartment of Psychiatry, School of Medicine, Medeniyet University, 34722 Istanbul, TurkeyDepartment of Psychiatry, School of Medicine, Atatürk University, 25240 Erzurum, TurkeyWe investigated the relationship of serum nitric oxide (NO) and asymmetrical dimethylarginine (ADMA) levels with cognitive functioning in patients with major depressive disorder (MDD). 41 MDD patients (Beck depression scale scores >16) and 44 controls were included in the study. Rey verbal learning and memory test, auditory consonant trigram test, digit span test, Wisconsin card sorting test, continuous performance task (TOVA), and Stroop test scores were found to be impaired in patients with major depressive disorder when compared to healthy controls. There was no significant difference between patient and control groups in terms of serum NO and ADMA. Serum NO levels were correlated with TOVA test error scores and Stroop test time scores, whereas serum ADMA levels were negatively correlated with TOVA test error scores. Metabolic detriments especially in relation to NO metabolism in frontal cortex and hypothalamus, psychomotor retardation, or loss of motivation may explain these deficits.http://dx.doi.org/10.1155/2014/624395 |
| spellingShingle | Serpil Canpolat İsmet Kırpınar Erdem Deveci Hülya Aksoy Zafer Bayraktutan İbrahim Eren Recep Demir Salih Selek Nazan Aydın Relationship of Asymmetrical Dimethylarginine, Nitric Oxide, and Sustained Attention during Attack in Patients with Major Depressive Disorder The Scientific World Journal |
| title | Relationship of Asymmetrical Dimethylarginine, Nitric Oxide, and Sustained Attention during Attack in Patients with Major Depressive Disorder |
| title_full | Relationship of Asymmetrical Dimethylarginine, Nitric Oxide, and Sustained Attention during Attack in Patients with Major Depressive Disorder |
| title_fullStr | Relationship of Asymmetrical Dimethylarginine, Nitric Oxide, and Sustained Attention during Attack in Patients with Major Depressive Disorder |
| title_full_unstemmed | Relationship of Asymmetrical Dimethylarginine, Nitric Oxide, and Sustained Attention during Attack in Patients with Major Depressive Disorder |
| title_short | Relationship of Asymmetrical Dimethylarginine, Nitric Oxide, and Sustained Attention during Attack in Patients with Major Depressive Disorder |
| title_sort | relationship of asymmetrical dimethylarginine nitric oxide and sustained attention during attack in patients with major depressive disorder |
| url | http://dx.doi.org/10.1155/2014/624395 |
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