3-Hydroxybutyrate alleviates septic liver injury by promoting macrophage polarization from M1 to M2

Objective To investigate the therapeutic effects and underlying mechanisms of the metabolite 3- hydroxybutyrate (3HB) in a cecal ligation and puncture (CLP)-induced sepsis model in mice. Methods Male C57BL / 6J mice were divided into three groups: Sham, CLP, and CLP + 3HB groups. The survival rate,...

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Bibliographic Details
Main Authors: Hu Jingjuan, Deng Fan, Sun Qishun, Min Yue, Feng Siyuan, Wu Ling, Chen Xiaofeng, Liu Kexuan
Format: Article
Language:zho
Published: Lanzhou University Press 2024-12-01
Series:生物医学转化
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Online Access:http://swyxzh.ijournals.cn/swyxzh/article/html/20240403
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