An improved bacterial single-cell RNA-seq reveals biofilm heterogeneity

An improved bacterial single-cell RNA-seq reveals biofilm heterogeneity

In contrast to mammalian cells, bacterial cells lack mRNA polyadenylated tails, presenting a hurdle in isolating mRNA amidst the prevalent rRNA during single-cell RNA-seq. This study introduces a novel method, ribosomal RNA-derived cDNA depletion (RiboD), seamlessly integrated into the PETRI-seq tec...

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Bibliographic Details
Main Authors: Xiaodan Yan, Hebin Liao, Chenyi Wang, Chun Huang, Wei Zhang, Chunming Guo, Yingying Pu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
bacterial scRNA-seq
biofilms
heterogeneity
Online Access:https://elifesciences.org/articles/97543
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https://elifesciences.org/articles/97543

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