Hippocampal Atrophy in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations
This study was conducted to explore hippocampal structural changes and their possible associations with clinical characteristics, emotional status, and treatment regimens in patients with systemic lupus erythematosus (SLE) without major neuropsychiatric manifestations (non-NPSLE). Eighty-five non-NP...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/2943848 |
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| _version_ | 1832547795058294784 |
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| author | Shuang Liu Yuqi Cheng Yueyin Zhao Aiyun Lai Zhaoping Lv Zhongqi Xie Bibhuti Upreti Xiangyu Wang Xiufeng Xu Chunrong Luo Hongjun Yu Baoci Shan Lin Xu Jian Xu |
| author_facet | Shuang Liu Yuqi Cheng Yueyin Zhao Aiyun Lai Zhaoping Lv Zhongqi Xie Bibhuti Upreti Xiangyu Wang Xiufeng Xu Chunrong Luo Hongjun Yu Baoci Shan Lin Xu Jian Xu |
| author_sort | Shuang Liu |
| collection | DOAJ |
| description | This study was conducted to explore hippocampal structural changes and their possible associations with clinical characteristics, emotional status, and treatment regimens in patients with systemic lupus erythematosus (SLE) without major neuropsychiatric manifestations (non-NPSLE). Eighty-five non-NPSLE patients with normal conventional magnetic resonance imaging (MRI) and seventy-seven matched healthy control (HC) subjects were recruited. All participants underwent the standard high-resolution volumetric MRI. The bilateral hippocampal volume (HIPV) and hippocampal density (HIPD) were calculated, respectively, for each participant. We found that the bilateral HIPV and HIPD of the SLE patient group were significantly less than those of the HC group. The bilateral HIPV of female patients were significantly less than those of male patients. The SLE disease activity index (SLEDAI) was negatively correlated with the bilateral HIPV and the right HIPD. Urine protein quantity was negatively correlated with the bilateral HIPV and HIPD. Hydroxychloroquine (HCQ) showed a protective effect on right HIPV. In conclusion, we found that the early hippocampal atrophy could occur before obvious neuropsychiatric manifestations and might be associated with SLE disease activity and organ damages. Early detection and intervention of hippocampal damage might prevent the progression to NPSLE. More studies are needed to fully understand the underlying mechanisms of hippocampal atrophy in SLE. |
| format | Article |
| id | doaj-art-9e4fcf9c28a94db3a599b9be92f34b53 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-9e4fcf9c28a94db3a599b9be92f34b532025-02-03T06:43:32ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/29438482943848Hippocampal Atrophy in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric ManifestationsShuang Liu0Yuqi Cheng1Yueyin Zhao2Aiyun Lai3Zhaoping Lv4Zhongqi Xie5Bibhuti Upreti6Xiangyu Wang7Xiufeng Xu8Chunrong Luo9Hongjun Yu10Baoci Shan11Lin Xu12Jian Xu13Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaYunnan Key Laboratory of Laboratory Medicine, Kunming 650032, ChinaDepartment of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaDepartment of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaDepartment of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaDepartment of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaDepartment of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaDepartment of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaDepartment of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaMagnetic Resonance Imaging Center, The First Hospital of Kunming, Kunming 650011, ChinaMagnetic Resonance Imaging Center, The First Hospital of Kunming, Kunming 650011, ChinaKey Laboratory of Nuclear Analysis, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, ChinaKey Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, ChinaDepartment of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaThis study was conducted to explore hippocampal structural changes and their possible associations with clinical characteristics, emotional status, and treatment regimens in patients with systemic lupus erythematosus (SLE) without major neuropsychiatric manifestations (non-NPSLE). Eighty-five non-NPSLE patients with normal conventional magnetic resonance imaging (MRI) and seventy-seven matched healthy control (HC) subjects were recruited. All participants underwent the standard high-resolution volumetric MRI. The bilateral hippocampal volume (HIPV) and hippocampal density (HIPD) were calculated, respectively, for each participant. We found that the bilateral HIPV and HIPD of the SLE patient group were significantly less than those of the HC group. The bilateral HIPV of female patients were significantly less than those of male patients. The SLE disease activity index (SLEDAI) was negatively correlated with the bilateral HIPV and the right HIPD. Urine protein quantity was negatively correlated with the bilateral HIPV and HIPD. Hydroxychloroquine (HCQ) showed a protective effect on right HIPV. In conclusion, we found that the early hippocampal atrophy could occur before obvious neuropsychiatric manifestations and might be associated with SLE disease activity and organ damages. Early detection and intervention of hippocampal damage might prevent the progression to NPSLE. More studies are needed to fully understand the underlying mechanisms of hippocampal atrophy in SLE.http://dx.doi.org/10.1155/2020/2943848 |
| spellingShingle | Shuang Liu Yuqi Cheng Yueyin Zhao Aiyun Lai Zhaoping Lv Zhongqi Xie Bibhuti Upreti Xiangyu Wang Xiufeng Xu Chunrong Luo Hongjun Yu Baoci Shan Lin Xu Jian Xu Hippocampal Atrophy in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations Journal of Immunology Research |
| title | Hippocampal Atrophy in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations |
| title_full | Hippocampal Atrophy in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations |
| title_fullStr | Hippocampal Atrophy in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations |
| title_full_unstemmed | Hippocampal Atrophy in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations |
| title_short | Hippocampal Atrophy in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations |
| title_sort | hippocampal atrophy in systemic lupus erythematosus patients without major neuropsychiatric manifestations |
| url | http://dx.doi.org/10.1155/2020/2943848 |
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