Population-specific DPYD variants and fluoropyrimidine toxicity risk: an analysis using public genomic databases
Introduction: Fluoropyrimidines (FP), including 5-fluorouracil (5-FU) and capecitabine, are widely used chemotherapeutic agents. However, their toxicity varies significantly among patients, often because of genetic differences in DPYD, which encodes dihydropyrimidine dehydrogenase, an enzyme crucial...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-07-01
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| Series: | Clinical Medicine |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1470211825001617 |
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