Population Pharmacokinetic Modeling of Total and Unbound Pamiparib in Glioblastoma Patients: Insights into Drug Disposition and Dosing Optimization

Population Pharmacokinetic Modeling of Total and Unbound Pamiparib in Glioblastoma Patients: Insights into Drug Disposition and Dosing Optimization

<b>Background:</b> This study aimed to develop a population pharmacokinetic (PK) model that characterized the plasma concentration–time profiles of the total and unbound pamiparib, a PARP inhibitor, in glioblastoma patients and identified patient factors influencing the PK. <b>Meth...

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Bibliographic Details
Main Authors: Charuka Wickramasinghe, Seongho Kim, Yuanyuan Jiang, Xun Bao, Yang Yue, Jun Jiang, Amy Hong, Nader Sanai, Jing Li
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Pharmaceutics
Subjects:
population pharmacokinetic model
pamiparib
PARP inhibitor
unbound plasma concentrations
dosing optimization
glioblastoma
Online Access:https://www.mdpi.com/1999-4923/17/4/524
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