Maturation and Emigration of Single-Positive Thymocytes
T lymphopoiesis in the thymus was thought to be completed once it reaches the single positive (SP) stage, a stage when T cells are “fully mature” and waiting to be exported at random or follow a “first-in-first-out” manner. Recent evidence, however, has revealed that the newly generated SP thymocyte...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/282870 |
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| _version_ | 1832558051129819136 |
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| author | Xi Xu Shusong Zhang Pingping Li Jin Lu Qun Xuan Qing Ge |
| author_facet | Xi Xu Shusong Zhang Pingping Li Jin Lu Qun Xuan Qing Ge |
| author_sort | Xi Xu |
| collection | DOAJ |
| description | T lymphopoiesis in the thymus was thought to be completed once it reaches the single positive (SP) stage, a stage when T cells are “fully mature” and waiting to be exported at random or follow a “first-in-first-out” manner. Recent evidence, however, has revealed that the newly generated SP thymocytes undergo a multistage maturation program in the thymic medulla. Such maturation is followed by a tightly regulated emigration process and a further postthymic maturation of recent thymic emigrants (RTEs). This review summarizes recent progress in the late stage T cell development. The regulation of this developmental process is discussed. |
| format | Article |
| id | doaj-art-9e208adf6d454883a415d2f68b17c037 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-9e208adf6d454883a415d2f68b17c0372025-02-03T01:33:21ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/282870282870Maturation and Emigration of Single-Positive ThymocytesXi Xu0Shusong Zhang1Pingping Li2Jin Lu3Qun Xuan4Qing Ge5Key Laboratory of Medical Immunology, Department of Immunology, Peking University Health Science Center, Ministry of Health, 38 Xue Yuan Road, Beijing 100191, ChinaKey Laboratory of Medical Immunology, Department of Immunology, Peking University Health Science Center, Ministry of Health, 38 Xue Yuan Road, Beijing 100191, ChinaKey Laboratory of Medical Immunology, Department of Immunology, Peking University Health Science Center, Ministry of Health, 38 Xue Yuan Road, Beijing 100191, ChinaPeking University Institute of Hematology, People’s Hospital, Beijing, ChinaDepartment of Microbiology and Immunology, Kunming Medical University, Kunming, ChinaKey Laboratory of Medical Immunology, Department of Immunology, Peking University Health Science Center, Ministry of Health, 38 Xue Yuan Road, Beijing 100191, ChinaT lymphopoiesis in the thymus was thought to be completed once it reaches the single positive (SP) stage, a stage when T cells are “fully mature” and waiting to be exported at random or follow a “first-in-first-out” manner. Recent evidence, however, has revealed that the newly generated SP thymocytes undergo a multistage maturation program in the thymic medulla. Such maturation is followed by a tightly regulated emigration process and a further postthymic maturation of recent thymic emigrants (RTEs). This review summarizes recent progress in the late stage T cell development. The regulation of this developmental process is discussed.http://dx.doi.org/10.1155/2013/282870 |
| spellingShingle | Xi Xu Shusong Zhang Pingping Li Jin Lu Qun Xuan Qing Ge Maturation and Emigration of Single-Positive Thymocytes Clinical and Developmental Immunology |
| title | Maturation and Emigration of Single-Positive Thymocytes |
| title_full | Maturation and Emigration of Single-Positive Thymocytes |
| title_fullStr | Maturation and Emigration of Single-Positive Thymocytes |
| title_full_unstemmed | Maturation and Emigration of Single-Positive Thymocytes |
| title_short | Maturation and Emigration of Single-Positive Thymocytes |
| title_sort | maturation and emigration of single positive thymocytes |
| url | http://dx.doi.org/10.1155/2013/282870 |
| work_keys_str_mv | AT xixu maturationandemigrationofsinglepositivethymocytes AT shusongzhang maturationandemigrationofsinglepositivethymocytes AT pingpingli maturationandemigrationofsinglepositivethymocytes AT jinlu maturationandemigrationofsinglepositivethymocytes AT qunxuan maturationandemigrationofsinglepositivethymocytes AT qingge maturationandemigrationofsinglepositivethymocytes |