Osteogenic effects and safety of human induced pluripotent stem cell-derived megakaryocytes and platelets produced on a clinical scale

Osteogenic effects and safety of human induced pluripotent stem cell-derived megakaryocytes and platelets produced on a clinical scale

Introduction: Platelet-rich plasma obtained by centrifuging peripheral blood can promote osteogenesis owing to its abundant growth factors but has drawbacks, including rapid growth factor loss and inconsistent effects depending on donor factors. To overcome these issues, we were the first in the wor...

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Main Authors: Takahito Arai, Yasuhiro Shiga, Michiaki Mukai, Naoya Takayama, Susumu Tashiro, Ikuko Tajiri, Kentaro Kosaka, Masashi Sato, Sou Nakamura, Haruki Okamoto, Seiji Kimura, Kazuhide Inage, Miyako Suzuki-Narita, Yawara Eguchi, Sumihisa Orita, Koji Eto, Seiji Ohtori
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Regenerative Therapy
Subjects:
Platelet-rich plasma
Freeze-dried human induced pluripotent stem cell-derived megakaryocytes and platelets
VerMES incubator
Osteogenesis
Lumber spine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320424001731
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