Galectin-3: A Novel Marker for the Prediction of Stroke Incidence and Clinical Prognosis
Stroke, whether ischemic or haemorrhagic, is one of the main causes of mortality and disability all over the world, which entails huge burdens in both healthcare environments as well as social and economic aspects of life. Therefore, there is a continuous search for novel reliable biomarkers that ca...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2022/2924773 |
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| author | Ahmed Sayed Malak Munir Mohamed S. Attia Badrah S. Alghamdi Ghulam Md Ashraf Eshak I. Bahbah Mohamed Elfil |
| author_facet | Ahmed Sayed Malak Munir Mohamed S. Attia Badrah S. Alghamdi Ghulam Md Ashraf Eshak I. Bahbah Mohamed Elfil |
| author_sort | Ahmed Sayed |
| collection | DOAJ |
| description | Stroke, whether ischemic or haemorrhagic, is one of the main causes of mortality and disability all over the world, which entails huge burdens in both healthcare environments as well as social and economic aspects of life. Therefore, there is a continuous search for novel reliable biomarkers that can enhance the recognition of stroke events in a timely manner and predict the clinical outcomes following a stroke event. Galectins are a group of proteins expressed by many types of cells and tissues including vasculature, certain immune cells, fibroblasts, and gastrointestinal epithelial cells. These proteins vary in their structure and configuration according to their type and have a diversity of functions according to the type of tissue they are expressed in. Among these proteins, a few studies investigated mainly the roles played by galectin-1 (Gal-1) and galectin-3 (Gal-3) in the molecular mechanisms of atherosclerosis and in brain tissue remodeling after a stroke event. In this review, we present an updated overview of the current understanding of Gal-3’s functions and implications in stroke occurrence and the response of the brain tissue to stroke events, which may be a key to its utility as a predictor of stroke incidence and clinical prognosis in the future. |
| format | Article |
| id | doaj-art-9d7df2c00a0646cdac0a6c440b030853 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9d7df2c00a0646cdac0a6c440b0308532025-02-03T05:50:06ZengWileyMediators of Inflammation1466-18612022-01-01202210.1155/2022/2924773Galectin-3: A Novel Marker for the Prediction of Stroke Incidence and Clinical PrognosisAhmed Sayed0Malak Munir1Mohamed S. Attia2Badrah S. Alghamdi3Ghulam Md Ashraf4Eshak I. Bahbah5Mohamed Elfil6Faculty of MedicineFaculty of MedicineDepartment of PharmaceuticsDepartment of PhysiologyPre-Clinical Research UnitFaculty of MedicineDepartment of Neurological SciencesStroke, whether ischemic or haemorrhagic, is one of the main causes of mortality and disability all over the world, which entails huge burdens in both healthcare environments as well as social and economic aspects of life. Therefore, there is a continuous search for novel reliable biomarkers that can enhance the recognition of stroke events in a timely manner and predict the clinical outcomes following a stroke event. Galectins are a group of proteins expressed by many types of cells and tissues including vasculature, certain immune cells, fibroblasts, and gastrointestinal epithelial cells. These proteins vary in their structure and configuration according to their type and have a diversity of functions according to the type of tissue they are expressed in. Among these proteins, a few studies investigated mainly the roles played by galectin-1 (Gal-1) and galectin-3 (Gal-3) in the molecular mechanisms of atherosclerosis and in brain tissue remodeling after a stroke event. In this review, we present an updated overview of the current understanding of Gal-3’s functions and implications in stroke occurrence and the response of the brain tissue to stroke events, which may be a key to its utility as a predictor of stroke incidence and clinical prognosis in the future.http://dx.doi.org/10.1155/2022/2924773 |
| spellingShingle | Ahmed Sayed Malak Munir Mohamed S. Attia Badrah S. Alghamdi Ghulam Md Ashraf Eshak I. Bahbah Mohamed Elfil Galectin-3: A Novel Marker for the Prediction of Stroke Incidence and Clinical Prognosis Mediators of Inflammation |
| title | Galectin-3: A Novel Marker for the Prediction of Stroke Incidence and Clinical Prognosis |
| title_full | Galectin-3: A Novel Marker for the Prediction of Stroke Incidence and Clinical Prognosis |
| title_fullStr | Galectin-3: A Novel Marker for the Prediction of Stroke Incidence and Clinical Prognosis |
| title_full_unstemmed | Galectin-3: A Novel Marker for the Prediction of Stroke Incidence and Clinical Prognosis |
| title_short | Galectin-3: A Novel Marker for the Prediction of Stroke Incidence and Clinical Prognosis |
| title_sort | galectin 3 a novel marker for the prediction of stroke incidence and clinical prognosis |
| url | http://dx.doi.org/10.1155/2022/2924773 |
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