<i>Ajuga reptans</i> L. Herb Extracts: Phytochemical Composition and Pharmacological Activity Screening
The genus <i>Ajuga</i> (Lamiaceae family) comprises approximately 300 species, which are widely used in traditional medicine for their diaphoretic, antiseptic, hemostatic, and anti-inflammatory properties, but scarcely in official ones. Therefore, the study of <i>Ajuga reptans</...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
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| Series: | Plants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2223-7747/14/2/219 |
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| Summary: | The genus <i>Ajuga</i> (Lamiaceae family) comprises approximately 300 species, which are widely used in traditional medicine for their diaphoretic, antiseptic, hemostatic, and anti-inflammatory properties, but scarcely in official ones. Therefore, the study of <i>Ajuga reptans</i> holds promise for developing new medicinal products. In aqueous and aqueous-alcoholic soft extracts of the <i>A. reptans</i> herb, 16 amino acids, 20 phenolics, and 10 volatile substances were identified by HPLC and GC/MS. The assays of the main substances’ groups were also determined by spectrophotometry (vitamin K1, polyphenols, tannins, flavonoids, and hydroxycinnamic acids) and titrometry (ascorbic and organic acids). <i>A. reptans</i> herb extracts are practically non-toxic, exhibit hepatoprotective activity (dose 25 mg/kg) in experimental carbon tetrachloride-induced hepatitis, moderate anti-inflammatory activity (dose 100 mg/kg) in carrageenan-induced edema models, and possess significant local hemostatic (reducing bleeding time by 40.6%) and wound-healing properties (complete wound healing after 9 days). The aqueous-ethanolic soft <i>A. reptans</i> extract (extractant 50% ethanol) demonstrated the most pronounced hepatoprotective and anti-inflammatory effects. <i>A. reptans</i> extracts are capable of inhibiting the growth of microorganisms and showing higher activity against Gram-positive bacteria. <i>A. reptans</i> herb extracts are promising agents for implementation in official medicine as wound healing and hepatoprotective remedies after further preclinical and clinical studies. |
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| ISSN: | 2223-7747 |