Novel Trispecific Neutralizing Antibodies With Enhanced Potency and Breadth Against Pan‐Sarbecoviruses

Novel Trispecific Neutralizing Antibodies With Enhanced Potency and Breadth Against Pan‐Sarbecoviruses

ABSTRACT The ongoing emergence of new variants of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) underscores the urgent need for developing antivirals targeting both SARS‐CoV‐2 variants and related sarbecoviruses. To this end, we designed novel trispecific antibodies, Tri‐1 and Tri...

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Main Authors: Rui Qiao, Yuanchen Liu, Qiyu Mao, Jiayan Li, Yinying Lu, Jialu Shi, Chen Li, Jizhen Yu, Jiami Gong, Xun Wang, Yuchen Shao, Lei Sun, Wenhong Zhang, Hongjie Yu, Hin Chu, Pengfei Wang, Xiaoyu Zhao
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:MedComm
Subjects:
coronavirus
sarbecovirus
SARS‐CoV‐2
bispecific antibody
trispecific antibody
broadly neutralizing antibody
Online Access:https://doi.org/10.1002/mco2.70191
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https://doi.org/10.1002/mco2.70191

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