New heterocyclic A1/A3 adenosine receptor ligands through molecular simplification strategies

New heterocyclic A1/A3 adenosine receptor ligands through molecular simplification strategies

In this paper we report the synthesis of new A1/A3 adenosine receptor antagonists designed as simplification products of the A1 antagonists with pyrazolo[1′,5′:1,6]pyrimido [4,5-d]pyridazin-4(3H)-one scaffold previously developed by us. Notably, selective A1R antagonists are promising therapeutic ag...

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Bibliographic Details
Main Authors: Letizia Crocetti, Abigail Pearce, Venkat S. Vege, Qi Xu, Jing Xu, Hannes Buthmann, Maria Paola Giovannoni, Gabriella Guerrini, Francesca Catarzi, Silvia Selleri, Xianglin Huang, Aneesh Chandran, Graham Ladds, Agostino Cilibrizzi
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
G protein-coupled receptor
Adenosine receptor
Antagonist
BRET
Binding
cAMP
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417425000093
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