Scale-up of CHO cell cultures: from 96-well-microtiter plates to stirred tank reactors across three orders of magnitude

Scale-up of CHO cell cultures: from 96-well-microtiter plates to stirred tank reactors across three orders of magnitude

Abstract Background For process development in mammalian cell cultivations, scale-up approaches are essential. A lot of studies concern the scale transfer between different-sized stirred tank reactors. However, process development usually starts in even smaller cultivation vessels like microtiter pl...

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Bibliographic Details
Main Authors: Anne Neuss, Thomas Steimann, Jacinta Sofia Tomas Borges, Robert Dinger, Jørgen Barsett Magnus
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Biological Engineering
Subjects:
Scale-up
Microtiter plates
Shake flasks
Stirred tank reactor
CHO cells
OTR
Online Access:https://doi.org/10.1186/s13036-024-00475-8
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