CircITSN1/EIF4A3/Itsn1 axis mediates postoperative cognitive dysfunction in aged mice: A novel mechanism and therapeutic target

CircITSN1/EIF4A3/Itsn1 axis mediates postoperative cognitive dysfunction in aged mice: A novel mechanism and therapeutic target

Circular RNAs (circRNAs) are stable noncoding RNAs that play a crucial role in neurodegenerative diseases, and they have been implicated in the pathogenesis of postoperative cognitive dysfunction (POCD). However, their underlying molecular mechanisms in POCD remain poorly understood. This study iden...

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Bibliographic Details
Main Authors: Changteng Zhang, Xiaoyu Zhu, Rui Gao, Hai Chen, Caiyi Yan, Wangyang Liu, Lina Yang, Xianzheng Zeng, Haoran Yang, Jin Liu, Qi Li, Daqing Ma, Tao Zhu, Chan Chen
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Non-coding RNAs
circRNA
postoperative cognitive dysfunction
circITSN1
intersection 1
EIF4A3
Online Access:http://www.sciencedirect.com/science/article/pii/S216225312500109X
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