Critical size defect in a rat calvaria model using trephination: An animal model for investigating potential bone regenerative scaffolds

Animal studies have been a key in vivo investigation in translating bioregenerative material into human clinical trials. The critical size defect (CSD) in a rat’s calvaria is a popular methodology for demonstrating and investigating the regenerative properties of a biomaterial. Various surgical appr...

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Bibliographic Details
Main Authors: Jeffrey Huang, Jithendra Ratnayake, George J. Dias
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:MethodsX
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2215016125002018
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