Efficacy of PDD-guided tumor excision combined with photodynamic therapy in cutaneous squamous cell carcinoma
Background: Cutaneous squamous cell carcinoma (cSCC) is an aggressive tumor with unclear margins. Photodynamic diagnosis (PDD) enables the differentiation of tumor tissue from normal tissue via visible fluorescence. Photodynamic therapy (PDT) is widely used in the treatment of non-melanoma skin tumo...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100024005052 |
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| author | Nan Yang Yunchuan Yang Wanqi Zhang Xinying Li Hao Jiang Huiling Kou Junbo Zhang Yuanyuan Wang Liuchang Tan Yuangang Lu |
| author_facet | Nan Yang Yunchuan Yang Wanqi Zhang Xinying Li Hao Jiang Huiling Kou Junbo Zhang Yuanyuan Wang Liuchang Tan Yuangang Lu |
| author_sort | Nan Yang |
| collection | DOAJ |
| description | Background: Cutaneous squamous cell carcinoma (cSCC) is an aggressive tumor with unclear margins. Photodynamic diagnosis (PDD) enables the differentiation of tumor tissue from normal tissue via visible fluorescence. Photodynamic therapy (PDT) is widely used in the treatment of non-melanoma skin tumors. This study aims to illustrate the efficacy and safety of PDD-guided tumor excision combined with ALA-PDT in patients with cSCC. Methods: This study involved 23 cSCC patients, randomly assigned to the PDD group (n = 11) and the non-PDD group (n = 12). Patients in the PDD group underwent tumor excision guided by PDD, while those in the non-PDD group received wide local excision (WLE). Both groups were subjected to frozen section analysis, and PDT was applied during and post-surgery. Results: The negative margin rate in the PDD group was 98.6 %, significantly higher than the 69.2 % observed in the non-PDD group. The PDD group required fewer frozen section analyses and experienced reduced surgical duration. Conclusions: PDD effectively delineates tumor margins in cSCC, guiding the scope of surgical excision. The integration of PDD-guided resection with PDT offers a highly safe and effective therapeutic strategy for cSCC. |
| format | Article |
| id | doaj-art-9d09f73deca04ecc9fa73a9ff559bad4 |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-9d09f73deca04ecc9fa73a9ff559bad42025-02-01T04:11:48ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-02-0151104469Efficacy of PDD-guided tumor excision combined with photodynamic therapy in cutaneous squamous cell carcinomaNan Yang0Yunchuan Yang1Wanqi Zhang2Xinying Li3Hao Jiang4Huiling Kou5Junbo Zhang6Yuanyuan Wang7Liuchang Tan8Yuangang Lu9Department of Plastic & Cosmetic Surgery, Daping Hospital, Army Medical University, Chongqing 400042, ChinaDepartment of Plastic & Cosmetic Surgery, Daping Hospital, Army Medical University, Chongqing 400042, ChinaDepartment of Plastic & Cosmetic Surgery, Daping Hospital, Army Medical University, Chongqing 400042, ChinaDepartment of Plastic & Cosmetic Surgery, Daping Hospital, Army Medical University, Chongqing 400042, ChinaDepartment of Plastic & Cosmetic Surgery, Daping Hospital, Army Medical University, Chongqing 400042, ChinaDepartment of Plastic & Cosmetic Surgery, Daping Hospital, Army Medical University, Chongqing 400042, ChinaDepartment of Plastic & Cosmetic Surgery, Daping Hospital, Army Medical University, Chongqing 400042, ChinaDepartment of Plastic & Cosmetic Surgery, Daping Hospital, Army Medical University, Chongqing 400042, ChinaDepartment of Plastic & Cosmetic Surgery, Daping Hospital, Army Medical University, Chongqing 400042, ChinaCorresponding author.; Department of Plastic & Cosmetic Surgery, Daping Hospital, Army Medical University, Chongqing 400042, ChinaBackground: Cutaneous squamous cell carcinoma (cSCC) is an aggressive tumor with unclear margins. Photodynamic diagnosis (PDD) enables the differentiation of tumor tissue from normal tissue via visible fluorescence. Photodynamic therapy (PDT) is widely used in the treatment of non-melanoma skin tumors. This study aims to illustrate the efficacy and safety of PDD-guided tumor excision combined with ALA-PDT in patients with cSCC. Methods: This study involved 23 cSCC patients, randomly assigned to the PDD group (n = 11) and the non-PDD group (n = 12). Patients in the PDD group underwent tumor excision guided by PDD, while those in the non-PDD group received wide local excision (WLE). Both groups were subjected to frozen section analysis, and PDT was applied during and post-surgery. Results: The negative margin rate in the PDD group was 98.6 %, significantly higher than the 69.2 % observed in the non-PDD group. The PDD group required fewer frozen section analyses and experienced reduced surgical duration. Conclusions: PDD effectively delineates tumor margins in cSCC, guiding the scope of surgical excision. The integration of PDD-guided resection with PDT offers a highly safe and effective therapeutic strategy for cSCC.http://www.sciencedirect.com/science/article/pii/S1572100024005052Cutaneous squamous cell carcinomaPhotodynamic therapyPhotodynamic diagnosisAminolevulinic acidSkin tumor |
| spellingShingle | Nan Yang Yunchuan Yang Wanqi Zhang Xinying Li Hao Jiang Huiling Kou Junbo Zhang Yuanyuan Wang Liuchang Tan Yuangang Lu Efficacy of PDD-guided tumor excision combined with photodynamic therapy in cutaneous squamous cell carcinoma Photodiagnosis and Photodynamic Therapy Cutaneous squamous cell carcinoma Photodynamic therapy Photodynamic diagnosis Aminolevulinic acid Skin tumor |
| title | Efficacy of PDD-guided tumor excision combined with photodynamic therapy in cutaneous squamous cell carcinoma |
| title_full | Efficacy of PDD-guided tumor excision combined with photodynamic therapy in cutaneous squamous cell carcinoma |
| title_fullStr | Efficacy of PDD-guided tumor excision combined with photodynamic therapy in cutaneous squamous cell carcinoma |
| title_full_unstemmed | Efficacy of PDD-guided tumor excision combined with photodynamic therapy in cutaneous squamous cell carcinoma |
| title_short | Efficacy of PDD-guided tumor excision combined with photodynamic therapy in cutaneous squamous cell carcinoma |
| title_sort | efficacy of pdd guided tumor excision combined with photodynamic therapy in cutaneous squamous cell carcinoma |
| topic | Cutaneous squamous cell carcinoma Photodynamic therapy Photodynamic diagnosis Aminolevulinic acid Skin tumor |
| url | http://www.sciencedirect.com/science/article/pii/S1572100024005052 |
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