Signaling Required for Blood Vessel Maintenance: Molecular Basis and Pathological Manifestations
As our understanding of molecular mechanisms leading to vascular formation increases, vessel maintenance including stabilization of new vessels and prevention of vessel regression began to be considered as an active process that requires specific cellular signaling. While signaling pathways such as...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/293641 |
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| _version_ | 1832560198439403520 |
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| author | Masahiro Murakami |
| author_facet | Masahiro Murakami |
| author_sort | Masahiro Murakami |
| collection | DOAJ |
| description | As our understanding of molecular mechanisms leading to vascular formation increases, vessel maintenance including stabilization of new vessels and prevention of vessel regression began to be considered as an active process that requires specific cellular signaling. While signaling pathways such as VEGF, FGF, and angiopoietin-Tie2 are important for endothelial cell survival and junction stabilization, PDGF and TGF-β signaling modify mural cell (vascular smooth muscle cells and pericytes) functions, thus they fortify vessel integrity. Breakdown of these signaling systems results in pathological hyperpermeability and/or genetic vascular abnormalities such as vascular malformations, ultimately progressing to hemorrhage and edema. Hence, blood vessel maintenance is fundamental to controlling vascular homeostasis and tissue functions. This paper discusses signaling pathways essential for vascular maintenance and clinical conditions caused by deterioration of vessel integrity. |
| format | Article |
| id | doaj-art-9ce6b51d78044ebabcca7052dcaa9db5 |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-9ce6b51d78044ebabcca7052dcaa9db52025-02-03T01:28:12ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322012-01-01201210.1155/2012/293641293641Signaling Required for Blood Vessel Maintenance: Molecular Basis and Pathological ManifestationsMasahiro Murakami0Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USAAs our understanding of molecular mechanisms leading to vascular formation increases, vessel maintenance including stabilization of new vessels and prevention of vessel regression began to be considered as an active process that requires specific cellular signaling. While signaling pathways such as VEGF, FGF, and angiopoietin-Tie2 are important for endothelial cell survival and junction stabilization, PDGF and TGF-β signaling modify mural cell (vascular smooth muscle cells and pericytes) functions, thus they fortify vessel integrity. Breakdown of these signaling systems results in pathological hyperpermeability and/or genetic vascular abnormalities such as vascular malformations, ultimately progressing to hemorrhage and edema. Hence, blood vessel maintenance is fundamental to controlling vascular homeostasis and tissue functions. This paper discusses signaling pathways essential for vascular maintenance and clinical conditions caused by deterioration of vessel integrity.http://dx.doi.org/10.1155/2012/293641 |
| spellingShingle | Masahiro Murakami Signaling Required for Blood Vessel Maintenance: Molecular Basis and Pathological Manifestations International Journal of Vascular Medicine |
| title | Signaling Required for Blood Vessel Maintenance: Molecular Basis and Pathological Manifestations |
| title_full | Signaling Required for Blood Vessel Maintenance: Molecular Basis and Pathological Manifestations |
| title_fullStr | Signaling Required for Blood Vessel Maintenance: Molecular Basis and Pathological Manifestations |
| title_full_unstemmed | Signaling Required for Blood Vessel Maintenance: Molecular Basis and Pathological Manifestations |
| title_short | Signaling Required for Blood Vessel Maintenance: Molecular Basis and Pathological Manifestations |
| title_sort | signaling required for blood vessel maintenance molecular basis and pathological manifestations |
| url | http://dx.doi.org/10.1155/2012/293641 |
| work_keys_str_mv | AT masahiromurakami signalingrequiredforbloodvesselmaintenancemolecularbasisandpathologicalmanifestations |