Visceral Leishmaniasis or Systemic Lupus Erythematosus Flare?
Systemic lupus erythematosus (SLE) is a multisystem disorder characterised by B-cell hyperactivity with production of multiple autoantibodies. Fever in SLE may be caused by disease exacerbation or by infection. We report a patient of SLE that was later complicated by fever, pancytopenia, and massive...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/523589 |
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| author | Sunny Garg Mousumi Kundu Amit Nandan Dhar Dwivedi Lalit Prashant Meena Neeraj Varyani Asif Iqbal Kamlakar Tripathi |
| author_facet | Sunny Garg Mousumi Kundu Amit Nandan Dhar Dwivedi Lalit Prashant Meena Neeraj Varyani Asif Iqbal Kamlakar Tripathi |
| author_sort | Sunny Garg |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a multisystem disorder characterised by B-cell hyperactivity with production of multiple autoantibodies. Fever in SLE may be caused by disease exacerbation or by infection. We report a patient of SLE that was later complicated by fever, pancytopenia, and massive splenomegaly. Corticosteroid therapy for SLE might have masked the underlying infection at earlier stage. Despite negative results of rk-39 test and bone marrow biopsy, a very high suspicion for visceral leishmaniasis (VL) led us to go for direct agglutination test (DAT) and polymerase chain reaction (PCR) for leishmanial antigen that revealed positive results. Moreover, significant improvement in clinical and biochemical parameters was noted on starting the patient on antileishmanial therapy. |
| format | Article |
| id | doaj-art-9ce3e97f2a4d4556bd1eb98485daf536 |
| institution | Kabale University |
| issn | 2090-6609 2090-6617 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Immunology |
| spelling | doaj-art-9ce3e97f2a4d4556bd1eb98485daf5362025-02-03T01:12:11ZengWileyCase Reports in Immunology2090-66092090-66172012-01-01201210.1155/2012/523589523589Visceral Leishmaniasis or Systemic Lupus Erythematosus Flare?Sunny Garg0Mousumi Kundu1Amit Nandan Dhar Dwivedi2Lalit Prashant Meena3Neeraj Varyani4Asif Iqbal5Kamlakar Tripathi6Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, IndiaDepartment of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, IndiaDepartment of Radiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, IndiaDepartment of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, IndiaDepartment of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, IndiaDepartment of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, IndiaDepartment of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, IndiaSystemic lupus erythematosus (SLE) is a multisystem disorder characterised by B-cell hyperactivity with production of multiple autoantibodies. Fever in SLE may be caused by disease exacerbation or by infection. We report a patient of SLE that was later complicated by fever, pancytopenia, and massive splenomegaly. Corticosteroid therapy for SLE might have masked the underlying infection at earlier stage. Despite negative results of rk-39 test and bone marrow biopsy, a very high suspicion for visceral leishmaniasis (VL) led us to go for direct agglutination test (DAT) and polymerase chain reaction (PCR) for leishmanial antigen that revealed positive results. Moreover, significant improvement in clinical and biochemical parameters was noted on starting the patient on antileishmanial therapy.http://dx.doi.org/10.1155/2012/523589 |
| spellingShingle | Sunny Garg Mousumi Kundu Amit Nandan Dhar Dwivedi Lalit Prashant Meena Neeraj Varyani Asif Iqbal Kamlakar Tripathi Visceral Leishmaniasis or Systemic Lupus Erythematosus Flare? Case Reports in Immunology |
| title | Visceral Leishmaniasis or Systemic Lupus Erythematosus Flare? |
| title_full | Visceral Leishmaniasis or Systemic Lupus Erythematosus Flare? |
| title_fullStr | Visceral Leishmaniasis or Systemic Lupus Erythematosus Flare? |
| title_full_unstemmed | Visceral Leishmaniasis or Systemic Lupus Erythematosus Flare? |
| title_short | Visceral Leishmaniasis or Systemic Lupus Erythematosus Flare? |
| title_sort | visceral leishmaniasis or systemic lupus erythematosus flare |
| url | http://dx.doi.org/10.1155/2012/523589 |
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