Cardiac secreted HSP90α exacerbates pressure overload myocardial hypertrophy and heart failure

Cardiac secreted HSP90α exacerbates pressure overload myocardial hypertrophy and heart failure

Sustained myocardial hypertrophy or left ventricular hypertrophy (LVH) triggered by pressure overload is strongly linked to adverse cardiovascular outcomes. Here, we investigated the clinical relationship between serum HSP90α (an isoform of HSP90) levels and LVH in patients with hypertension or aort...

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Bibliographic Details
Main Authors: Le Pan, Chenxing Huang, Xuejuan Jin, Jian Wu, Kejia Jin, Jingyi Lin, Ying Wang, Jianxuan Li, Chao Yin, Xiang Wang, Lei Zhang, Guoping Zhang, Hangming Dong, Junli Guo, Issei Komuro, Yuxiang Dai, Yunzeng Zou, Hui Gong
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Redox Biology
Subjects:
HSP90
Cardiac hypertrophy
Pressure overload
Heart failure
β-catenin
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724004440
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