Influence of the Sex of Translocation Carrier on Clinical Outcomes of Couples Undergoing Preimplantation Genetic Testing
ABSTRACT Introduction This study investigated the impact of the carrier on transferable blastocyst rate and live birth outcomes in couples with structural chromosomal abnormalities. Methods Couples were grouped into reciprocal translocation, Robertsonian translocation, or inversions groups, and clin...
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2025-01-01
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| Series: | Molecular Genetics & Genomic Medicine |
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| Online Access: | https://doi.org/10.1002/mgg3.70050 |
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| author | Zhiping Zhang Jiayao Chen Lei Zhang Ruiyang Wei Zhen Liu Dunmei Zhao Xingyu Bi Lixia Liang Xueluo Zhang Dan Su Xueqing Wu |
| author_facet | Zhiping Zhang Jiayao Chen Lei Zhang Ruiyang Wei Zhen Liu Dunmei Zhao Xingyu Bi Lixia Liang Xueluo Zhang Dan Su Xueqing Wu |
| author_sort | Zhiping Zhang |
| collection | DOAJ |
| description | ABSTRACT Introduction This study investigated the impact of the carrier on transferable blastocyst rate and live birth outcomes in couples with structural chromosomal abnormalities. Methods Couples were grouped into reciprocal translocation, Robertsonian translocation, or inversions groups, and clinical data were retrospectively analyzed. Preimplantation genetic testing for chromosomal structural rearrangements (PGT‐SR) was conducted, and pregnancy outcomes were compared. Results Embryo euploidy rates between male and female carriers differed nonsignificantly in the reciprocal translocation and inversion groups but significantly among the three groups. In the Robertsonian translocation group, male carriers had a higher embryo euploidy rate than that of female carriers. Sperm density of male carriers with reciprocal and Robertsonian translocation was significantly lower than that of the female carrier in the same group, whereas the difference was non‐significant in the inversion group. The clinical outcomes of embryo transfer post‐PGT were similar regardless of the sex of carriers with structural chromosomal abnormalities. Female carriers with Robertsonian translocations displayed a higher risk of producing embryos with chromosomal abnormalities than male carriers. Pregnancy, live birth, and cumulative live birth rates following a PGT‐SR cycle were similar, irrespective of chromosomal structural rearrangement type, and carrier sex. Conclusion Our findings offer valuable information for genetic counseling. |
| format | Article |
| id | doaj-art-9c930dbab9c145f29ac5a644e4fc5a49 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | Molecular Genetics & Genomic Medicine |
| spelling | doaj-art-9c930dbab9c145f29ac5a644e4fc5a492025-01-24T08:16:42ZengWileyMolecular Genetics & Genomic Medicine2324-92692025-01-01131n/an/a10.1002/mgg3.70050Influence of the Sex of Translocation Carrier on Clinical Outcomes of Couples Undergoing Preimplantation Genetic TestingZhiping Zhang0Jiayao Chen1Lei Zhang2Ruiyang Wei3Zhen Liu4Dunmei Zhao5Xingyu Bi6Lixia Liang7Xueluo Zhang8Dan Su9Xueqing Wu10Center of Reproductive Medicine Affiliated Children's Hospital of Shanxi & Women Health Center of Shanxi Medicine University Taiyuan Shanxi ChinaCenter of Reproductive Medicine Affiliated Children's Hospital of Shanxi & Women Health Center of Shanxi Medicine University Taiyuan Shanxi ChinaCenter of Reproductive Medicine Affiliated Children's Hospital of Shanxi & Women Health Center of Shanxi Medicine University Taiyuan Shanxi ChinaYikon Genomics Company Ltd. Suzhou ChinaYikon Genomics Company Ltd. Suzhou ChinaYikon Genomics Company Ltd. Suzhou ChinaCenter of Reproductive Medicine Affiliated Children's Hospital of Shanxi & Women Health Center of Shanxi Medicine University Taiyuan Shanxi ChinaCenter of Reproductive Medicine Affiliated Children's Hospital of Shanxi & Women Health Center of Shanxi Medicine University Taiyuan Shanxi ChinaCenter of Reproductive Medicine Affiliated Children's Hospital of Shanxi & Women Health Center of Shanxi Medicine University Taiyuan Shanxi ChinaCenter of Reproductive Medicine Affiliated Children's Hospital of Shanxi & Women Health Center of Shanxi Medicine University Taiyuan Shanxi ChinaCenter of Reproductive Medicine Affiliated Children's Hospital of Shanxi & Women Health Center of Shanxi Medicine University Taiyuan Shanxi ChinaABSTRACT Introduction This study investigated the impact of the carrier on transferable blastocyst rate and live birth outcomes in couples with structural chromosomal abnormalities. Methods Couples were grouped into reciprocal translocation, Robertsonian translocation, or inversions groups, and clinical data were retrospectively analyzed. Preimplantation genetic testing for chromosomal structural rearrangements (PGT‐SR) was conducted, and pregnancy outcomes were compared. Results Embryo euploidy rates between male and female carriers differed nonsignificantly in the reciprocal translocation and inversion groups but significantly among the three groups. In the Robertsonian translocation group, male carriers had a higher embryo euploidy rate than that of female carriers. Sperm density of male carriers with reciprocal and Robertsonian translocation was significantly lower than that of the female carrier in the same group, whereas the difference was non‐significant in the inversion group. The clinical outcomes of embryo transfer post‐PGT were similar regardless of the sex of carriers with structural chromosomal abnormalities. Female carriers with Robertsonian translocations displayed a higher risk of producing embryos with chromosomal abnormalities than male carriers. Pregnancy, live birth, and cumulative live birth rates following a PGT‐SR cycle were similar, irrespective of chromosomal structural rearrangement type, and carrier sex. Conclusion Our findings offer valuable information for genetic counseling.https://doi.org/10.1002/mgg3.70050embryo euploidy ratepregnancy outcomespreimplantation genetic testing for chromosomal structural rearrangementsstructural chromosomal abnormalitiestransferable blastocyst rate |
| spellingShingle | Zhiping Zhang Jiayao Chen Lei Zhang Ruiyang Wei Zhen Liu Dunmei Zhao Xingyu Bi Lixia Liang Xueluo Zhang Dan Su Xueqing Wu Influence of the Sex of Translocation Carrier on Clinical Outcomes of Couples Undergoing Preimplantation Genetic Testing Molecular Genetics & Genomic Medicine embryo euploidy rate pregnancy outcomes preimplantation genetic testing for chromosomal structural rearrangements structural chromosomal abnormalities transferable blastocyst rate |
| title | Influence of the Sex of Translocation Carrier on Clinical Outcomes of Couples Undergoing Preimplantation Genetic Testing |
| title_full | Influence of the Sex of Translocation Carrier on Clinical Outcomes of Couples Undergoing Preimplantation Genetic Testing |
| title_fullStr | Influence of the Sex of Translocation Carrier on Clinical Outcomes of Couples Undergoing Preimplantation Genetic Testing |
| title_full_unstemmed | Influence of the Sex of Translocation Carrier on Clinical Outcomes of Couples Undergoing Preimplantation Genetic Testing |
| title_short | Influence of the Sex of Translocation Carrier on Clinical Outcomes of Couples Undergoing Preimplantation Genetic Testing |
| title_sort | influence of the sex of translocation carrier on clinical outcomes of couples undergoing preimplantation genetic testing |
| topic | embryo euploidy rate pregnancy outcomes preimplantation genetic testing for chromosomal structural rearrangements structural chromosomal abnormalities transferable blastocyst rate |
| url | https://doi.org/10.1002/mgg3.70050 |
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