Endocan in Cancers: A Lesson from a Circulating Dermatan Sulfate Proteoglycan
As most proteoglycans exert their biological activities in the pericellular region, circulating Endocan has appeared since its discovery as an atypical dermatan sulfate proteoglycan, with distinctive structural and functional properties. Endocan is naturally expressed by endothelial cells, highly re...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2013/705027 |
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| _version_ | 1832563233767030784 |
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| author | Maryse Delehedde Lucie Devenyns Claude-Alain Maurage Romain R. Vivès |
| author_facet | Maryse Delehedde Lucie Devenyns Claude-Alain Maurage Romain R. Vivès |
| author_sort | Maryse Delehedde |
| collection | DOAJ |
| description | As most proteoglycans exert their biological activities in the pericellular region, circulating Endocan has appeared since its discovery as an atypical dermatan sulfate proteoglycan, with distinctive structural and functional properties. Endocan is naturally expressed by endothelial cells, highly regulated in presence of proinflammatory and proangiogenic molecules, binds to matrix proteins, growth factors, integrin, and cells, and may be then considered as an accurate marker of endothelial activation. Consequently, Endocan expression has been associated with a growing number of pathological conditions where endothelium gets challenged and notably in highly vascularized cancers. In this context, Endocan has indeed been rapidly emerging as a promising tissue- and blood-based marker of the vascular growth and neoangiogenesis during cancer progression. Furthermore, very recent studies have reported an expression of Endocan by the tumor cells themselves. This highlights Endocan as a multifaceted molecule with a great interest for researchers and clinicians to better understand tumor development, from the bench to the clinics. With promising perspectives of clinical applications, Endocan thus appears as an exciting model for on going and future developments of proteoglycan-based approaches in cancer diagnostics and/or therapy. |
| format | Article |
| id | doaj-art-9c6b14e25cce4e52a229a3cec58436de |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-9c6b14e25cce4e52a229a3cec58436de2025-02-03T01:20:41ZengWileyInternational Journal of Cell Biology1687-88761687-88842013-01-01201310.1155/2013/705027705027Endocan in Cancers: A Lesson from a Circulating Dermatan Sulfate ProteoglycanMaryse Delehedde0Lucie Devenyns1Claude-Alain Maurage2Romain R. Vivès3Lunginnov, Campus de l'Institut Pasteur de Lille, 59000 Lille, FranceLunginnov, Campus de l'Institut Pasteur de Lille, 59000 Lille, FranceCentre de Biologie-Pathologie-Génétique, Centre Hospitalier Régional Universitaire de Lille, 59037 Lille Cedex, FranceInstitut de Biologie Structurale Jean-Pierre Ebel, Unité Mixte de Recherche (UMR) 5075, CNRS-CEA-Université Joseph Fourier, 38027 Grenoble, FranceAs most proteoglycans exert their biological activities in the pericellular region, circulating Endocan has appeared since its discovery as an atypical dermatan sulfate proteoglycan, with distinctive structural and functional properties. Endocan is naturally expressed by endothelial cells, highly regulated in presence of proinflammatory and proangiogenic molecules, binds to matrix proteins, growth factors, integrin, and cells, and may be then considered as an accurate marker of endothelial activation. Consequently, Endocan expression has been associated with a growing number of pathological conditions where endothelium gets challenged and notably in highly vascularized cancers. In this context, Endocan has indeed been rapidly emerging as a promising tissue- and blood-based marker of the vascular growth and neoangiogenesis during cancer progression. Furthermore, very recent studies have reported an expression of Endocan by the tumor cells themselves. This highlights Endocan as a multifaceted molecule with a great interest for researchers and clinicians to better understand tumor development, from the bench to the clinics. With promising perspectives of clinical applications, Endocan thus appears as an exciting model for on going and future developments of proteoglycan-based approaches in cancer diagnostics and/or therapy.http://dx.doi.org/10.1155/2013/705027 |
| spellingShingle | Maryse Delehedde Lucie Devenyns Claude-Alain Maurage Romain R. Vivès Endocan in Cancers: A Lesson from a Circulating Dermatan Sulfate Proteoglycan International Journal of Cell Biology |
| title | Endocan in Cancers: A Lesson from a Circulating Dermatan Sulfate Proteoglycan |
| title_full | Endocan in Cancers: A Lesson from a Circulating Dermatan Sulfate Proteoglycan |
| title_fullStr | Endocan in Cancers: A Lesson from a Circulating Dermatan Sulfate Proteoglycan |
| title_full_unstemmed | Endocan in Cancers: A Lesson from a Circulating Dermatan Sulfate Proteoglycan |
| title_short | Endocan in Cancers: A Lesson from a Circulating Dermatan Sulfate Proteoglycan |
| title_sort | endocan in cancers a lesson from a circulating dermatan sulfate proteoglycan |
| url | http://dx.doi.org/10.1155/2013/705027 |
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