Spatial microfluidic holographic integrated platform for label-free and high-dimensional analysis of cancer heterogeneity

Abstract The combination of quantitative phase microscopy (QPM) with imaging flow cytometry (IFC) enables label-free and multi-parameter single-cell analysis. Here, we present a simple yet powerful QPM-IFC platform, the spatial microfluidic holographic integrated (SMHI) platform, which uniquely inte...

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Bibliographic Details
Main Authors: Jiayi Shi, Huijing Teng, Ziyi Zhang, Yanping Liu, Dan Gao, Jianglei Di, Zijian Yang, Ping Su, Ying Tan, Jianshe Ma
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60897-w
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