Comparison of prophylactic topical application of Cryptomphalus aspersa secretion versus betamethasone for telecobalt radiation-induced skin reactions in locally advanced head and neck carcinoma patients
Background: External beam radiation therapy (EBRT) with or without concurrent chemotherapy is practiced as backbone of treatment across sites and subsites of head and neck cancer (HNC) when the intent is definitive. Radiation-induced acute skin reaction is of major concern during and after definitiv...
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Manipal College of Medical Sciences, Pokhara
2025-02-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://ajmsjournal.info/index.php/AJMS/article/view/4307 |
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| author | Ramashish Kumar Ashok Chauhan Sovan Sarang Dhar Nitish Kumar |
| author_facet | Ramashish Kumar Ashok Chauhan Sovan Sarang Dhar Nitish Kumar |
| author_sort | Ramashish Kumar |
| collection | DOAJ |
| description | Background: External beam radiation therapy (EBRT) with or without concurrent chemotherapy is practiced as backbone of treatment across sites and subsites of head and neck cancer (HNC) when the intent is definitive. Radiation-induced acute skin reaction is of major concern during and after definitive course of radiotherapy. Prevention and treatment of these reactions play an important role in the completion of the prescribed course of EBRT within stipulated time period while maintaining the quality of life.
Aims and Objectives: The aim of the study was to compare results of topical Cryptomphalus aspersa secretion versus betamethasone cream for radiation-induced acute skin reactions in locally advanced head and neck carcinoma patients undergoing definitive irradiation from telecobalt and concurrent chemotherapy.
Materials and Methods: A prospective randomized study was conducted to compare the topical application of C. aspersa secretion 4% cream (Study Group) versus betamethasone 0.1% ointment (Control Group) for the management of radiation-induced skin reactions in locally advanced head and neck carcinoma treated with concomitant chemoradiation. Thirty patients in each of the two groups were treated with radical EBRT 66 Gy/33 fractions/6.5 weeks (5 fractions/week) concomitant with Cisplatin 100 mg/m2 every 3 weeks.
Results: Grade 3 skin reactions were observed in 11 (36.67%) and 12 (40%) patients in the Control Group at the 6th week and at completion of treatment, respectively. There were no Grade 3 skin reactions in the Study Group. The difference in the development of skin reactions observed was statistically significant at 6th week, at completion of treatment as well as at the 1st month of follow-up (grade-1) between the two groups (P<0.001).
Conclusion: Prophylactic application of topical C. aspersa secretion delays the emergence of skin reactions of HNC patients during telecobalt radiation treatment, prevents appearance of Grade 3 or higher skin reactions, and also repairs them faster as compared to betamethasone topical preparation. |
| format | Article |
| id | doaj-art-9c362dda687f48b08f0bb84f2873fac9 |
| institution | Kabale University |
| issn | 2467-9100 2091-0576 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj-art-9c362dda687f48b08f0bb84f2873fac92025-02-01T12:25:36ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762025-02-01162103110https://doi.org/10.71152/ajms.v16i2.4307Comparison of prophylactic topical application of Cryptomphalus aspersa secretion versus betamethasone for telecobalt radiation-induced skin reactions in locally advanced head and neck carcinoma patientsRamashish Kumar0https://orcid.org/0009-0008-4568-4684Ashok Chauhan 1Sovan Sarang Dhar 2https://orcid.org/0000-0003-4001-6229Nitish Kumar 3https://orcid.org/0009-0003-6717-9172Senior Resident, Department of Radiation Oncology, Lady Hardinge Medical College and SSK Hospital, New Delhi, India Professor and Head, Department of Radiation Oncology, Pt. B D Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, IndiaAssistant Professor, Department of Radiation Oncology, Lady Hardinge Medical College and SSK Hospital, New Delhi, India Senior Resident, Department of Radiation Oncology, Lady Hardinge Medical College and SSK Hospital, New Delhi, India Background: External beam radiation therapy (EBRT) with or without concurrent chemotherapy is practiced as backbone of treatment across sites and subsites of head and neck cancer (HNC) when the intent is definitive. Radiation-induced acute skin reaction is of major concern during and after definitive course of radiotherapy. Prevention and treatment of these reactions play an important role in the completion of the prescribed course of EBRT within stipulated time period while maintaining the quality of life. Aims and Objectives: The aim of the study was to compare results of topical Cryptomphalus aspersa secretion versus betamethasone cream for radiation-induced acute skin reactions in locally advanced head and neck carcinoma patients undergoing definitive irradiation from telecobalt and concurrent chemotherapy. Materials and Methods: A prospective randomized study was conducted to compare the topical application of C. aspersa secretion 4% cream (Study Group) versus betamethasone 0.1% ointment (Control Group) for the management of radiation-induced skin reactions in locally advanced head and neck carcinoma treated with concomitant chemoradiation. Thirty patients in each of the two groups were treated with radical EBRT 66 Gy/33 fractions/6.5 weeks (5 fractions/week) concomitant with Cisplatin 100 mg/m2 every 3 weeks. Results: Grade 3 skin reactions were observed in 11 (36.67%) and 12 (40%) patients in the Control Group at the 6th week and at completion of treatment, respectively. There were no Grade 3 skin reactions in the Study Group. The difference in the development of skin reactions observed was statistically significant at 6th week, at completion of treatment as well as at the 1st month of follow-up (grade-1) between the two groups (P<0.001). Conclusion: Prophylactic application of topical C. aspersa secretion delays the emergence of skin reactions of HNC patients during telecobalt radiation treatment, prevents appearance of Grade 3 or higher skin reactions, and also repairs them faster as compared to betamethasone topical preparation.https://ajmsjournal.info/index.php/AJMS/article/view/4307grade 3 acute skin toxicity; head and neck cancer; telecobalt; external beam radiation therapy; acute radiodermatitis; treatment; prevention; betamethasone; cryptomphalus aspersa secretion |
| spellingShingle | Ramashish Kumar Ashok Chauhan Sovan Sarang Dhar Nitish Kumar Comparison of prophylactic topical application of Cryptomphalus aspersa secretion versus betamethasone for telecobalt radiation-induced skin reactions in locally advanced head and neck carcinoma patients Asian Journal of Medical Sciences grade 3 acute skin toxicity; head and neck cancer; telecobalt; external beam radiation therapy; acute radiodermatitis; treatment; prevention; betamethasone; cryptomphalus aspersa secretion |
| title | Comparison of prophylactic topical application of Cryptomphalus aspersa secretion versus betamethasone for telecobalt radiation-induced skin reactions in locally advanced head and neck carcinoma patients |
| title_full | Comparison of prophylactic topical application of Cryptomphalus aspersa secretion versus betamethasone for telecobalt radiation-induced skin reactions in locally advanced head and neck carcinoma patients |
| title_fullStr | Comparison of prophylactic topical application of Cryptomphalus aspersa secretion versus betamethasone for telecobalt radiation-induced skin reactions in locally advanced head and neck carcinoma patients |
| title_full_unstemmed | Comparison of prophylactic topical application of Cryptomphalus aspersa secretion versus betamethasone for telecobalt radiation-induced skin reactions in locally advanced head and neck carcinoma patients |
| title_short | Comparison of prophylactic topical application of Cryptomphalus aspersa secretion versus betamethasone for telecobalt radiation-induced skin reactions in locally advanced head and neck carcinoma patients |
| title_sort | comparison of prophylactic topical application of cryptomphalus aspersa secretion versus betamethasone for telecobalt radiation induced skin reactions in locally advanced head and neck carcinoma patients |
| topic | grade 3 acute skin toxicity; head and neck cancer; telecobalt; external beam radiation therapy; acute radiodermatitis; treatment; prevention; betamethasone; cryptomphalus aspersa secretion |
| url | https://ajmsjournal.info/index.php/AJMS/article/view/4307 |
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