Gain in 1q is a Common Abnormality in Phyllodes Tumours of the Breast
We studied DNA copy number changes by CGH and allelic imbalance (AI) on 3p by LOH analysis on 22 phyllodes tumours (PT) of the breast in order to gain insight into the genetic basis of tumour progression in PT. Copy number changes were observed in 14 cases (63%). Gain in 1q with 1q21–23 as the minim...
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| Format: | Article |
| Language: | English |
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Wiley
2003-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2003/803192 |
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| author | Kowan J. Jee Gyungyub Gong Sei Hyun Ahn Jeong Mi Park Sakari Knuutila |
| author_facet | Kowan J. Jee Gyungyub Gong Sei Hyun Ahn Jeong Mi Park Sakari Knuutila |
| author_sort | Kowan J. Jee |
| collection | DOAJ |
| description | We studied DNA copy number changes by CGH and allelic imbalance (AI) on 3p by LOH analysis on 22 phyllodes tumours (PT) of the breast in order to gain insight into the genetic basis of tumour progression in PT. Copy number changes were observed in 14 cases (63%). Gain in 1q with 1q21–23 as the minimal overlapping area was seen in 12 cases (55%). The gain was observed both in benign and malignant tumours. Our study did not reveal any DNA copy number changes or allelic loss on 3p. The results suggest that DNA copy number changes are not associated with the histological grade or clinical behaviour of PT and the chromosomal changes on 3p appear to be rare. Colour figure can be viewed on http://www.esacp.org/acp/2003/25‐2/jee.htm. |
| format | Article |
| id | doaj-art-9c12b29d8541463dbc963436e2e07b65 |
| institution | Kabale University |
| issn | 0921-8912 1878-3651 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-9c12b29d8541463dbc963436e2e07b652025-02-03T06:07:15ZengWileyAnalytical Cellular Pathology0921-89121878-36512003-01-01252899310.1155/2003/803192Gain in 1q is a Common Abnormality in Phyllodes Tumours of the BreastKowan J. Jee0Gyungyub Gong1Sei Hyun Ahn2Jeong Mi Park3Sakari Knuutila4Departments of Pathology and Medical Genetics, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, FinlandDepartment of Pathology, University of Ulsan, College of Medicine, ASAN Medical Center, Seoul, South KoreaDepartment of General Surgery, University of Ulsan, College of Medicine, ASAN Medical Center, Seoul, South KoreaDepartment of Diagnostic Radiology, University of Ulsan, College of Medicine, ASAN Medical Center, Seoul, South KoreaDepartments of Pathology and Medical Genetics, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, FinlandWe studied DNA copy number changes by CGH and allelic imbalance (AI) on 3p by LOH analysis on 22 phyllodes tumours (PT) of the breast in order to gain insight into the genetic basis of tumour progression in PT. Copy number changes were observed in 14 cases (63%). Gain in 1q with 1q21–23 as the minimal overlapping area was seen in 12 cases (55%). The gain was observed both in benign and malignant tumours. Our study did not reveal any DNA copy number changes or allelic loss on 3p. The results suggest that DNA copy number changes are not associated with the histological grade or clinical behaviour of PT and the chromosomal changes on 3p appear to be rare. Colour figure can be viewed on http://www.esacp.org/acp/2003/25‐2/jee.htm.http://dx.doi.org/10.1155/2003/803192 |
| spellingShingle | Kowan J. Jee Gyungyub Gong Sei Hyun Ahn Jeong Mi Park Sakari Knuutila Gain in 1q is a Common Abnormality in Phyllodes Tumours of the Breast Analytical Cellular Pathology |
| title | Gain in 1q is a Common Abnormality in Phyllodes Tumours of the Breast |
| title_full | Gain in 1q is a Common Abnormality in Phyllodes Tumours of the Breast |
| title_fullStr | Gain in 1q is a Common Abnormality in Phyllodes Tumours of the Breast |
| title_full_unstemmed | Gain in 1q is a Common Abnormality in Phyllodes Tumours of the Breast |
| title_short | Gain in 1q is a Common Abnormality in Phyllodes Tumours of the Breast |
| title_sort | gain in 1q is a common abnormality in phyllodes tumours of the breast |
| url | http://dx.doi.org/10.1155/2003/803192 |
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