Utilization of Cardiac Magnetic Resonance Imaging for Assessing Myocardial Fibrosis in Prognosis Evaluation and Risk Stratification of Patients with Dilated Cardiomyopathy
Dilated cardiomyopathy (DCM) is the ultimate manifestation of the myocardial response to various genetic and environmental changes and is characterized mainly by impaired left ventricular systolic and diastolic function. DCM can ultimately lead to heart failure, ventricular arrhythmia (VA), and sudd...
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| Format: | Article |
| Language: | English |
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IMR Press
2025-01-01
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| Series: | Reviews in Cardiovascular Medicine |
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| Online Access: | https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM25654 |
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| author | Xin-Yi Feng Yu-Cong Zheng Ying-Xia Yang Wen-Feng He Fan Yang Ling-Li Wang Han-Feng Yang Chun-Ping Li Xiao-Xue Xu Rui Li |
| author_facet | Xin-Yi Feng Yu-Cong Zheng Ying-Xia Yang Wen-Feng He Fan Yang Ling-Li Wang Han-Feng Yang Chun-Ping Li Xiao-Xue Xu Rui Li |
| author_sort | Xin-Yi Feng |
| collection | DOAJ |
| description | Dilated cardiomyopathy (DCM) is the ultimate manifestation of the myocardial response to various genetic and environmental changes and is characterized mainly by impaired left ventricular systolic and diastolic function. DCM can ultimately lead to heart failure, ventricular arrhythmia (VA), and sudden cardiac death (SCD), making it a primary indication for heart transplantation. With advancements in modern medicine, several novel techniques for evaluating myocardial involvement and disease severity from diverse perspectives have been developed. Myocardial fibrosis is a significant contributor to VA events and SCD. Based on different pathological mechanisms, myocardial fibrosis can be categorized into replacement and interstitial forms. Late gadolinium enhancement (LGE) derived from cardiovascular magnetic resonance is the clinical gold standard for evaluating replacement myocardial fibrosis and exhibits high concordance with histological replacement fibrosis. However, because of the absence of normal tissue as a control, the LGE technique often fails to effectively visualize diffuse interstitial fibrosis. In such cases, T1 mapping and extracellular volume fraction mapping can be complementary or alternative methods to the LGE technique for detecting interstitial fibrosis. This review aimed to provide a comprehensive and precise assessment of myocardial fibrosis and to determine the use of cardiac magnetic resonance imaging for prognostic evaluation and risk stratification of patients with DCM. |
| format | Article |
| id | doaj-art-9c098a14270c413690dee51d22b5cc1c |
| institution | Kabale University |
| issn | 1530-6550 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj-art-9c098a14270c413690dee51d22b5cc1c2025-01-25T10:41:19ZengIMR PressReviews in Cardiovascular Medicine1530-65502025-01-012612565410.31083/RCM25654S1530-6550(24)01587-4Utilization of Cardiac Magnetic Resonance Imaging for Assessing Myocardial Fibrosis in Prognosis Evaluation and Risk Stratification of Patients with Dilated CardiomyopathyXin-Yi Feng0Yu-Cong Zheng1Ying-Xia Yang2Wen-Feng He3Fan Yang4Ling-Li Wang5Han-Feng Yang6Chun-Ping Li7Xiao-Xue Xu8Rui Li9Department of Radiology, Affiliated Hospital of North Sichuan Medical College, 637000 Nanchong, Sichuan, ChinaDepartment of Radiology, Tsinghua University Hospital, Tsinghua University, 100084 Beijing, ChinaDepartment of Radiology, Guangxi Hospital Division of The First Affiliated Hospital, Sun Yat-sen University, 530021 Nanning, Guangxi, ChinaDepartment of Cardiology, Affiliated Hospital of North Sichuan Medical College, 637000 Nanchong, Sichuan, ChinaDepartment of Radiology, Affiliated Hospital of North Sichuan Medical College, 637000 Nanchong, Sichuan, ChinaDepartment of Radiology, Affiliated Hospital of North Sichuan Medical College, 637000 Nanchong, Sichuan, ChinaDepartment of Radiology, Affiliated Hospital of North Sichuan Medical College, 637000 Nanchong, Sichuan, ChinaDepartment of Radiology, Affiliated Hospital of North Sichuan Medical College, 637000 Nanchong, Sichuan, ChinaDepartment of Radiology, Affiliated Hospital of North Sichuan Medical College, 637000 Nanchong, Sichuan, ChinaDepartment of Radiology, Affiliated Hospital of North Sichuan Medical College, 637000 Nanchong, Sichuan, ChinaDilated cardiomyopathy (DCM) is the ultimate manifestation of the myocardial response to various genetic and environmental changes and is characterized mainly by impaired left ventricular systolic and diastolic function. DCM can ultimately lead to heart failure, ventricular arrhythmia (VA), and sudden cardiac death (SCD), making it a primary indication for heart transplantation. With advancements in modern medicine, several novel techniques for evaluating myocardial involvement and disease severity from diverse perspectives have been developed. Myocardial fibrosis is a significant contributor to VA events and SCD. Based on different pathological mechanisms, myocardial fibrosis can be categorized into replacement and interstitial forms. Late gadolinium enhancement (LGE) derived from cardiovascular magnetic resonance is the clinical gold standard for evaluating replacement myocardial fibrosis and exhibits high concordance with histological replacement fibrosis. However, because of the absence of normal tissue as a control, the LGE technique often fails to effectively visualize diffuse interstitial fibrosis. In such cases, T1 mapping and extracellular volume fraction mapping can be complementary or alternative methods to the LGE technique for detecting interstitial fibrosis. This review aimed to provide a comprehensive and precise assessment of myocardial fibrosis and to determine the use of cardiac magnetic resonance imaging for prognostic evaluation and risk stratification of patients with DCM.https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM25654cardiac magnetic resonancedilated cardiomyopathymyocardial fibrosislate gadolinium enhancementt1 mapping imagingprognosis |
| spellingShingle | Xin-Yi Feng Yu-Cong Zheng Ying-Xia Yang Wen-Feng He Fan Yang Ling-Li Wang Han-Feng Yang Chun-Ping Li Xiao-Xue Xu Rui Li Utilization of Cardiac Magnetic Resonance Imaging for Assessing Myocardial Fibrosis in Prognosis Evaluation and Risk Stratification of Patients with Dilated Cardiomyopathy Reviews in Cardiovascular Medicine cardiac magnetic resonance dilated cardiomyopathy myocardial fibrosis late gadolinium enhancement t1 mapping imaging prognosis |
| title | Utilization of Cardiac Magnetic Resonance Imaging for Assessing Myocardial Fibrosis in Prognosis Evaluation and Risk Stratification of Patients with Dilated Cardiomyopathy |
| title_full | Utilization of Cardiac Magnetic Resonance Imaging for Assessing Myocardial Fibrosis in Prognosis Evaluation and Risk Stratification of Patients with Dilated Cardiomyopathy |
| title_fullStr | Utilization of Cardiac Magnetic Resonance Imaging for Assessing Myocardial Fibrosis in Prognosis Evaluation and Risk Stratification of Patients with Dilated Cardiomyopathy |
| title_full_unstemmed | Utilization of Cardiac Magnetic Resonance Imaging for Assessing Myocardial Fibrosis in Prognosis Evaluation and Risk Stratification of Patients with Dilated Cardiomyopathy |
| title_short | Utilization of Cardiac Magnetic Resonance Imaging for Assessing Myocardial Fibrosis in Prognosis Evaluation and Risk Stratification of Patients with Dilated Cardiomyopathy |
| title_sort | utilization of cardiac magnetic resonance imaging for assessing myocardial fibrosis in prognosis evaluation and risk stratification of patients with dilated cardiomyopathy |
| topic | cardiac magnetic resonance dilated cardiomyopathy myocardial fibrosis late gadolinium enhancement t1 mapping imaging prognosis |
| url | https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM25654 |
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