Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases
tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs made of specific tRNA cleavage. They play regulatory roles in several biological contexts such as cancer...
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| Format: | Article |
| Language: | English |
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BioMed Central
2015-12-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gni-13-94.pdf |
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| _version_ | 1832572359474675712 |
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| author | Yu Fu Inhan Lee Yong Sun Lee Xiaoyong Bao |
| author_facet | Yu Fu Inhan Lee Yong Sun Lee Xiaoyong Bao |
| author_sort | Yu Fu |
| collection | DOAJ |
| description | tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs made of specific tRNA cleavage. They play regulatory roles in several biological contexts such as cancer, innate immunity, stress responses, and neurological disorders. In this review, we summarize the biogenesis and functions of tRFs. |
| format | Article |
| id | doaj-art-9c036ba16e5c4784b3a53c26e3832077 |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2015-12-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-9c036ba16e5c4784b3a53c26e38320772025-02-02T10:43:43ZengBioMed CentralGenomics & Informatics1598-866X2234-07422015-12-011349410110.5808/GI.2015.13.4.94162Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human DiseasesYu Fu0Inhan Lee1Yong Sun Lee2Xiaoyong Bao3Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, USA.miRcore, Ann Arbor, MI 48105, USA.Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, USA.tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs made of specific tRNA cleavage. They play regulatory roles in several biological contexts such as cancer, innate immunity, stress responses, and neurological disorders. In this review, we summarize the biogenesis and functions of tRFs.http://genominfo.org/upload/pdf/gni-13-94.pdfneoplasmsneurodegenerative diseasesRSV replication, tRNA, tRNA-derived RNA fragments |
| spellingShingle | Yu Fu Inhan Lee Yong Sun Lee Xiaoyong Bao Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases Genomics & Informatics neoplasms neurodegenerative diseases RSV replication, tRNA, tRNA-derived RNA fragments |
| title | Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases |
| title_full | Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases |
| title_fullStr | Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases |
| title_full_unstemmed | Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases |
| title_short | Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases |
| title_sort | small non coding transfer rna derived rna fragments trfs their biogenesis function and implication in human diseases |
| topic | neoplasms neurodegenerative diseases RSV replication, tRNA, tRNA-derived RNA fragments |
| url | http://genominfo.org/upload/pdf/gni-13-94.pdf |
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