Overproduction of Phenolic Compounds in <i>Pseudomonas putida</i> KT2440 Through Endogen Deregulation of the Shikimate Pathway

Overproduction of Phenolic Compounds in <i>Pseudomonas putida</i> KT2440 Through Endogen Deregulation of the Shikimate Pathway

Metabolic engineering of the shikimate pathway offers a promising strategy for enhancing the production of aromatic compounds in microbial hosts. However, feedback inhibition of key enzymes, such as the 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAHP synthase), often limits the yield of t...

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Bibliographic Details
Main Authors: William Merre, Ricardo Andrade, Cyril Perot, Alexia Chandor-Proust, Caroline Ranquet
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:BioChem
Subjects:
feedback resistance
DAHP synthase
<i>Pseudomonas putida</i>
enzyme engineering
shikimate pathway
p-coumaric acid
Online Access:https://www.mdpi.com/2673-6411/5/1/4
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