Antithyroid Antibodies and Thyroid Function in Pediatric Patients with Celiac Disease
Objective. Aim of the study was to determine the prevalence of autoimmune thyroid disease, persistence of antithyroid antibodies, effect of gluten-free diet, and long-term outcome of thyroid function in pediatric patients with celiac disease (CD). Methods. 67 patients with CD aged from 1 year to 16...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/276575 |
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| author | Derya Kalyoncu Nafiye Urganci |
| author_facet | Derya Kalyoncu Nafiye Urganci |
| author_sort | Derya Kalyoncu |
| collection | DOAJ |
| description | Objective. Aim of the study was to determine the prevalence of autoimmune thyroid disease, persistence of antithyroid antibodies, effect of gluten-free diet, and long-term outcome of thyroid function in pediatric patients with celiac disease (CD). Methods. 67 patients with CD aged from 1 year to 16 years were screened for thyroid antithyroperoxidase, antithyroglobulin and anti-TSH receptor antibodies, serum free triiodothyronine, free thyroxine, and thyroid-stimulating hormone (TSH) at diagnosis and during follow-up. Results. None of the patients had antithyroid antibodies at diagnosis. Antithyroid antibodies became positive in 16.4% of the patients (11/67) 2 to 3 years after the diagnosis of CD. Clinical hypothyroidism was observed only in 3 of 11 CD patients with positive antithyroid antibodies (27.2%). The antithyroid antibodies positive and negative patients did not differ significantly according to compliance to GFD (P>0.05). A statistically significant difference was observed only in age, in which the patients with positive antithyroid antibodies were younger than the patients with negative antithyroid antibodies (P=0.004). None of the patients had any change in their thyroid function and antibody profile during their follow-up. Conclusion. Antithyroid antibodies were detected in younger pediatric patients with CD and the prevalence of antithyroid antibodies did not correlate with the duration of gluten intake. |
| format | Article |
| id | doaj-art-9bcc0238f4e44f3c9cb6acae2cf0a1d5 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-9bcc0238f4e44f3c9cb6acae2cf0a1d52025-02-03T01:03:20ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/276575276575Antithyroid Antibodies and Thyroid Function in Pediatric Patients with Celiac DiseaseDerya Kalyoncu0Nafiye Urganci1Department of Pediatrics, Sisli Etfal Training and Research Hospital, 34270 Istanbul, TurkeyDivision of Pediatric Gastroenterology, Sisli Etfal Training and Research Hospital, 34270 Istanbul, TurkeyObjective. Aim of the study was to determine the prevalence of autoimmune thyroid disease, persistence of antithyroid antibodies, effect of gluten-free diet, and long-term outcome of thyroid function in pediatric patients with celiac disease (CD). Methods. 67 patients with CD aged from 1 year to 16 years were screened for thyroid antithyroperoxidase, antithyroglobulin and anti-TSH receptor antibodies, serum free triiodothyronine, free thyroxine, and thyroid-stimulating hormone (TSH) at diagnosis and during follow-up. Results. None of the patients had antithyroid antibodies at diagnosis. Antithyroid antibodies became positive in 16.4% of the patients (11/67) 2 to 3 years after the diagnosis of CD. Clinical hypothyroidism was observed only in 3 of 11 CD patients with positive antithyroid antibodies (27.2%). The antithyroid antibodies positive and negative patients did not differ significantly according to compliance to GFD (P>0.05). A statistically significant difference was observed only in age, in which the patients with positive antithyroid antibodies were younger than the patients with negative antithyroid antibodies (P=0.004). None of the patients had any change in their thyroid function and antibody profile during their follow-up. Conclusion. Antithyroid antibodies were detected in younger pediatric patients with CD and the prevalence of antithyroid antibodies did not correlate with the duration of gluten intake.http://dx.doi.org/10.1155/2015/276575 |
| spellingShingle | Derya Kalyoncu Nafiye Urganci Antithyroid Antibodies and Thyroid Function in Pediatric Patients with Celiac Disease International Journal of Endocrinology |
| title | Antithyroid Antibodies and Thyroid Function in Pediatric Patients with Celiac Disease |
| title_full | Antithyroid Antibodies and Thyroid Function in Pediatric Patients with Celiac Disease |
| title_fullStr | Antithyroid Antibodies and Thyroid Function in Pediatric Patients with Celiac Disease |
| title_full_unstemmed | Antithyroid Antibodies and Thyroid Function in Pediatric Patients with Celiac Disease |
| title_short | Antithyroid Antibodies and Thyroid Function in Pediatric Patients with Celiac Disease |
| title_sort | antithyroid antibodies and thyroid function in pediatric patients with celiac disease |
| url | http://dx.doi.org/10.1155/2015/276575 |
| work_keys_str_mv | AT deryakalyoncu antithyroidantibodiesandthyroidfunctioninpediatricpatientswithceliacdisease AT nafiyeurganci antithyroidantibodiesandthyroidfunctioninpediatricpatientswithceliacdisease |