Possibility of using a mouse SCID as a model animal to variola virus for evaluating anti-smallpox drug efficacy

Possibility of using a mouse SCID as a model animal to variola virus for evaluating anti-smallpox drug efficacy

At present, there is no animal model for smallpox that reflects the weakened immune system in people and can therefore help assess the prophylactic (highly preventive) efficiency of antiviral drugs. To fill in the gap, we have explored the possibility of using outbred immunodeficient SCID mice as a...

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Bibliographic Details
Main Authors: K. A. Titova, Al. A. Sergeev, A. S. Kabanov, L. E. Bulychev, Ar. A. Sergeev, D. O. Galahova, A. S. Zamedyanskaya, L. N. Shishkina, O. S. Taranov, V. V. Omigov, E. L. Zavjalov, A. P. Agafonov, A. N. Sergeev
Format: Article
Language:English
Published: Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders 2015-12-01
Series:Вавиловский журнал генетики и селекции
Subjects:
variola virus
scid mouse
animal model
intranasal infection
50 % infectious dose
dissemination of the virus
pathological damage
prophylactic efficacy
Online Access:https://vavilov.elpub.ru/jour/article/view/440
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