Single-cell sequencing reveals cell heterogeneity and aberrantly activated pathways associated with microvascular invasion in hepatocellular carcinoma

Single-cell sequencing reveals cell heterogeneity and aberrantly activated pathways associated with microvascular invasion in hepatocellular carcinoma

IntroductionHepatocellular carcinoma (HCC) is the most common primary liver cancer, with microvascular invasion (MVI) identified as a major predictor of early recurrence. However, the intratumor cellular heterogeneity of MVI, the identification of pertinent biomarkers, and the role of intercellular...

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Bibliographic Details
Main Authors: Jianwei Cui, Fanyi Zeng, Ming Tang, Shiwu Yin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
single-cell RNA-sequencing
hepatocellular carcinoma
microvascular invasion
MARCKSL1 gene
prognostic signature
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1449624/full
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