Social Experience-Dependent Myelination: An Implication for Psychiatric Disorders
Myelination is one of the strategies to promote the conduction velocity of axons in order to adjust to evolving environment in vertebrates. It has been shown that myelin formation depends on genetic programing and experience, including multiple factors, intracellular and extracellular molecules, and...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2015/465345 |
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| _version_ | 1832566225718214656 |
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| author | Michihiro Toritsuka Manabu Makinodan Toshifumi Kishimoto |
| author_facet | Michihiro Toritsuka Manabu Makinodan Toshifumi Kishimoto |
| author_sort | Michihiro Toritsuka |
| collection | DOAJ |
| description | Myelination is one of the strategies to promote the conduction velocity of axons in order to adjust to evolving environment in vertebrates. It has been shown that myelin formation depends on genetic programing and experience, including multiple factors, intracellular and extracellular molecules, and neuronal activities. Recently, accumulating studies have shown that myelination in the central nervous system changes more dynamically in response to neuronal activities and experience than expected. Among experiences, social experience-dependent myelination draws attention as one of the critical pathobiologies of psychiatric disorders. In this review, we summarize the mechanisms of neuronal activity-dependent and social experience-dependent myelination and discuss the contribution of social experience-dependent myelination to the pathology of psychiatric disorders. |
| format | Article |
| id | doaj-art-9b7f645c07504f7e932a824a1d46355c |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-9b7f645c07504f7e932a824a1d46355c2025-02-03T01:04:52ZengWileyNeural Plasticity2090-59041687-54432015-01-01201510.1155/2015/465345465345Social Experience-Dependent Myelination: An Implication for Psychiatric DisordersMichihiro Toritsuka0Manabu Makinodan1Toshifumi Kishimoto2Department of Psychiatry, Faculty of Medicine, Nara Medical University, 840 Shijo-cho Kashihara, Nara 634-8522, JapanDepartment of Psychiatry, Faculty of Medicine, Nara Medical University, 840 Shijo-cho Kashihara, Nara 634-8522, JapanDepartment of Psychiatry, Faculty of Medicine, Nara Medical University, 840 Shijo-cho Kashihara, Nara 634-8522, JapanMyelination is one of the strategies to promote the conduction velocity of axons in order to adjust to evolving environment in vertebrates. It has been shown that myelin formation depends on genetic programing and experience, including multiple factors, intracellular and extracellular molecules, and neuronal activities. Recently, accumulating studies have shown that myelination in the central nervous system changes more dynamically in response to neuronal activities and experience than expected. Among experiences, social experience-dependent myelination draws attention as one of the critical pathobiologies of psychiatric disorders. In this review, we summarize the mechanisms of neuronal activity-dependent and social experience-dependent myelination and discuss the contribution of social experience-dependent myelination to the pathology of psychiatric disorders.http://dx.doi.org/10.1155/2015/465345 |
| spellingShingle | Michihiro Toritsuka Manabu Makinodan Toshifumi Kishimoto Social Experience-Dependent Myelination: An Implication for Psychiatric Disorders Neural Plasticity |
| title | Social Experience-Dependent Myelination: An Implication for Psychiatric Disorders |
| title_full | Social Experience-Dependent Myelination: An Implication for Psychiatric Disorders |
| title_fullStr | Social Experience-Dependent Myelination: An Implication for Psychiatric Disorders |
| title_full_unstemmed | Social Experience-Dependent Myelination: An Implication for Psychiatric Disorders |
| title_short | Social Experience-Dependent Myelination: An Implication for Psychiatric Disorders |
| title_sort | social experience dependent myelination an implication for psychiatric disorders |
| url | http://dx.doi.org/10.1155/2015/465345 |
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