Cell-specific transcriptional signatures of vascular cells in Alzheimer’s disease: perspectives, pathways, and therapeutic directions

Cell-specific transcriptional signatures of vascular cells in Alzheimer’s disease: perspectives, pathways, and therapeutic directions

Abstract Alzheimer’s disease (AD) is a debilitating neurodegenerative disease that is marked by profound neurovascular dysfunction and significant cell-specific alterations in the brain vasculature. Recent advances in high throughput single-cell transcriptomics technology have enabled the study of t...

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Bibliographic Details
Main Authors: Soumilee Chaudhuri, Minyoung Cho, Julia C. Stumpff, Paula J. Bice, Özkan İş, Nilüfer Ertekin-Taner, Andrew J. Saykin, Kwangsik Nho
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease (AD)
Single cell or single nuclei transcriptomics (scRNAseq or snRNAseq)
Cerebrovascular cells
Neurovascular unit (NVU)
Endothelial cells
Smooth muscle cells
Online Access:https://doi.org/10.1186/s13024-025-00798-0
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https://doi.org/10.1186/s13024-025-00798-0

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