Dual orexin receptor antagonists as promising therapeutics for Alzheimer’s disease

Abstract We examine the relationship between sleep, glymphatics and Alzheimer’s disease (AD), and recent work questioning glymphatic clearance during sleep. We highlight a need for understanding glymphatic and/or other mechanism of clearance during sleep, and review glymphatic flow measurement metho...

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Bibliographic Details
Main Authors: S. M. Ragsdale, J. M. Radovich, I. I. Coiduras, W. V. McCall, S. C. Grant, C. Lee, A. Wilber
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:npj Biological Timing and Sleep
Online Access:https://doi.org/10.1038/s44323-025-00025-5
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