Microwave Assisted Heterocyclization: A Rapid and Efficient Synthesis and Antibacterial Activity of Novel Thiazolidinones
As a target to synthesize various Thiazolidinone derivatives, 2-Amino-4-(coumarin-3-yl)-thiazole has been prepared by the reactions of 3-Bromo acetyl coumarin with thiourea. 3-Bromo acetyl coumarin was prepared from 3-Acetyl coumarin. The resulting compound 2-amino-4-(coumarin-3-yl)- thiazole was tr...
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| Format: | Article |
| Language: | English |
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Wiley
2004-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2004/435147 |
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| author | B. D. Naik K. R. Desai |
| author_facet | B. D. Naik K. R. Desai |
| author_sort | B. D. Naik |
| collection | DOAJ |
| description | As a target to synthesize various Thiazolidinone derivatives, 2-Amino-4-(coumarin-3-yl)-thiazole has been prepared by the reactions of 3-Bromo acetyl coumarin with thiourea. 3-Bromo acetyl coumarin was prepared from 3-Acetyl coumarin. The resulting compound 2-amino-4-(coumarin-3-yl)- thiazole was treated with different Aldehydes to give the intermediate Schiff base, which on further reaction with Thioglycolic acid and Thiolactic acid to give titled compound Thiazolidinone. The structures of the compounds have been confirmed by elemental analysis and spectral analysis. The antibacterial activity of the compounds has also been screened against Staphylococcus aureus and Escherichia coil. |
| format | Article |
| id | doaj-art-9b63c628a3544d43a5aaf824acf869a9 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-9b63c628a3544d43a5aaf824acf869a92025-02-03T05:52:00ZengWileyE-Journal of Chemistry0973-49452090-98102004-01-011526326610.1155/2004/435147Microwave Assisted Heterocyclization: A Rapid and Efficient Synthesis and Antibacterial Activity of Novel ThiazolidinonesB. D. Naik0K. R. Desai1Department of Chemistry, South Gujarat University, Surat-395 007, IndiaDepartment of Chemistry, South Gujarat University, Surat-395 007, IndiaAs a target to synthesize various Thiazolidinone derivatives, 2-Amino-4-(coumarin-3-yl)-thiazole has been prepared by the reactions of 3-Bromo acetyl coumarin with thiourea. 3-Bromo acetyl coumarin was prepared from 3-Acetyl coumarin. The resulting compound 2-amino-4-(coumarin-3-yl)- thiazole was treated with different Aldehydes to give the intermediate Schiff base, which on further reaction with Thioglycolic acid and Thiolactic acid to give titled compound Thiazolidinone. The structures of the compounds have been confirmed by elemental analysis and spectral analysis. The antibacterial activity of the compounds has also been screened against Staphylococcus aureus and Escherichia coil.http://dx.doi.org/10.1155/2004/435147 |
| spellingShingle | B. D. Naik K. R. Desai Microwave Assisted Heterocyclization: A Rapid and Efficient Synthesis and Antibacterial Activity of Novel Thiazolidinones E-Journal of Chemistry |
| title | Microwave Assisted Heterocyclization: A Rapid and Efficient Synthesis and Antibacterial Activity of Novel Thiazolidinones |
| title_full | Microwave Assisted Heterocyclization: A Rapid and Efficient Synthesis and Antibacterial Activity of Novel Thiazolidinones |
| title_fullStr | Microwave Assisted Heterocyclization: A Rapid and Efficient Synthesis and Antibacterial Activity of Novel Thiazolidinones |
| title_full_unstemmed | Microwave Assisted Heterocyclization: A Rapid and Efficient Synthesis and Antibacterial Activity of Novel Thiazolidinones |
| title_short | Microwave Assisted Heterocyclization: A Rapid and Efficient Synthesis and Antibacterial Activity of Novel Thiazolidinones |
| title_sort | microwave assisted heterocyclization a rapid and efficient synthesis and antibacterial activity of novel thiazolidinones |
| url | http://dx.doi.org/10.1155/2004/435147 |
| work_keys_str_mv | AT bdnaik microwaveassistedheterocyclizationarapidandefficientsynthesisandantibacterialactivityofnovelthiazolidinones AT krdesai microwaveassistedheterocyclizationarapidandefficientsynthesisandantibacterialactivityofnovelthiazolidinones |